The E3 ubiquitin ligase WWP1 (WW Domain-containing E3 Ubiquitin Protein Ligase 1) is a
member of the HECT (Homologous to the E6-associated protein Carboxyl Terminus) E3 …

UBR box E3 ligases, also called N-recognins, are integral components of the N-degron
pathway. Representative N-recognins include UBR1, UBR2, UBR4, and UBR5, and they …

Forty years ago, ubiquitin was first discovered as a posttranslational modification earmarking
proteins for degradation [1]. This seminal, biochemical work laid the foundation for countless …

The human UBR5 is a single polypeptide chain homology to E6AP C terminus (HECT)-type
E3 ubiquitin ligase essential for embryonic development in mammals. Dysregulated UBR5 …

Ubiquitylation is a posttranslational modification of proteins that is necessary for a variety of
cellular processes. E1 ubiquitin activating enzyme, E2 ubiquitin conjugating enzyme, and E3 …

With global climate change, it is essential to find strategies to make crops more resistant to
different stresses and guarantee food security worldwide. E3 ubiquitin ligases are critical …

Abstract Background Rice (Oryza sativa L.) is one of the globally important staple food crops,
and yield-related traits are prerequisites for improved breeding efficiency in rice. Here, we …

The ubiquitin-proteasome system (UPS) modulates carcinogenesis through ubiquitination of
cancer-related target proteins, leading to their degradation in the proteasome. This may …

The proteasome plays vital roles in eukaryotic cells by orchestrating the regulated
degradation of large repertoires of substrates involved in numerous biological processes …

The Ubiquitin Proteasome System (UPS) is responsible for the degradation of misfolded or
aggregated proteins via a multistep ATP-dependent proteolytic mechanism. This process …