The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …

Mitochondria are essential for the viability of eukaryotic cells as they perform crucial
functions in bioenergetics, metabolism and signalling and have been associated with …

The mammalian mitochondrial proteome is under dual genomic control, with 99% of proteins
encoded by the nuclear genome and 13 originating from the mitochondrial DNA (mtDNA) …

Tau (MAPT) drives neuronal dysfunction in Alzheimer disease (AD) and other tauopathies.
To dissect the underlying mechanisms, we combined an engineered ascorbic acid …

Mitochondria are key organelles for cellular energetics, metabolism, signaling, and quality
control and have been linked to various diseases. Different views exist on the composition of …

This protocol describes the use of TurboID and split-TurboID in proximity labeling
applications for map** protein–protein interactions and subcellular proteomes in live …

Mitochondria, which play central roles in immunometabolic diseases, have their own
genome. However, the functions of mitochondria-located noncoding RNAs are largely …

INTRODUCTION A complete view of human biology can only be achieved by studying the
molecular components of its smallest functional unit, the cell. Cells are internally organized …

Stress granules (SGs) are transient ribonucleoprotein (RNP) aggregates that form during
cellular stress and are increasingly implicated in human neurodegeneration. To study the …

In the mitochondrial outer membrane, α-helical transmembrane proteins play critical roles in
cytoplasmic-mitochondrial communication. Using genome-wide CRISPR screens, we …