Thyroid hormone transporters at the plasma membrane govern intracellular bioavailability of
thyroid hormone. Monocarboxylate transporter (MCT) 8 and MCT10, organic anion …

The thyroid hormones, thyroxine (T 4) and triiodothyronine (T 3), are essential for normal
growth and development of the fetus. Their bioavailability in utero depends on development …

Behavioral epigenetics is revealing new pathways that lead individuals from early adversity
exposures to later-in-life detrimental outcomes. Preterm birth constitutes one of the major …

Endothelial dysfunction is an important risk factor for cardiovascular disease, and it
represents the initial step in the pathogenesis of atherosclerosis. Failure to protect against …

Context: Mutations in the MCT8 (SLC16A2) gene, encoding a specific thyroid hormone
transporter, cause an X-linked disease with profound psychomotor retardation, neurological …

Thyroid hormones and iodine are required to increase basal metabolic rate and to regulate
protein synthesis, long bone growth and neuronal maturation. They are also essential for …

The essential roles of thyroid hormone (TH) in perinatal brain development have been
known for decades. More recently, many of the molecular mechanisms underlying the …

DNA methylation (DNAm) plays a determining role in neural cell fate and provides a
molecular link between early-life stress and neuropsychiatric disease. Preterm birth is a …

Thyroid hormone is essential for fetal (brain) development. Plasma membrane transporters
control the intracellular bioavailability of thyroid hormone. In the past few decades, 15 …

Thyroid hormone (TH) transport into the brain is not only pivotal for development and
differentiation, but also for maintenance and regulation of adult central nervous system …