Non-coding RNAs: the riddle of the transcriptome and their perspectives in cancer

MA Diamantopoulos, P Tsiakanikas… - Annals of translational …, 2018 - pmc.ncbi.nlm.nih.gov
Non-coding RNAs (ncRNAs) constitute a heterogeneous group of RNA molecules in terms
of biogenesis, biological function as well as length and structure. These biological …

Identification of Two Novel Circular RNAs Deriving from BCL2L12 and Investigation of Their Potential Value as a Molecular Signature in Colorectal Cancer

P Karousi, PI Artemaki, CD Sotiropoulou… - International Journal of …, 2020 - mdpi.com
The utility of circular RNAs (circRNAs) as molecular biomarkers has recently emerged.
However, only a handful of them have already been studied in colorectal cancer (CRC). The …

Kallikrein-related peptidases and associated microRNAs as promising prognostic biomarkers in gastrointestinal malignancies

PG Adamopoulos, P Tsiakanikas, A Scorilas - Biological Chemistry, 2018 - degruyter.com
Gastrointestinal (GI) malignancies represent a wide spectrum of diseases of the GI tract and
its accessory digestive organs, including esophageal (EC), gastric (GC), hepatocellular …

Identification of a novel human E‐cadherin splice variant and assessment of its effects upon EMT‐related events

ML Matos, L Lapyckyj, M Rosso… - Journal of cellular …, 2017 - Wiley Online Library
Epithelial Cadherin (E‐cadherin) is involved in calcium‐dependent cell–cell adhesion and
signal transduction. The E‐cadherin decrease/loss is a hallmark of Epithelial to …

Novel alternative splice variants of the human protein arginine methyltransferase 1 (PRMT1) gene, discovered using next-generation sequencing

PG Adamopoulos, AV Mavrogiannis, CK Kontos… - Gene, 2019 - Elsevier
Next-generation sequencing (NGS) technology is highly expected to help researchers
disclose the complexity of alternative splicing and understand its association with …

[HTML][HTML] Unraveling novel survivin mRNA transcripts in cancer cells using an in-house developed targeted high-throughput sequencing approach

PG Adamopoulos, P Tsiakanikas, EE Adam, A Scorilas - Genomics, 2021 - Elsevier
The human baculoviral IAP repeat containing 5 (BIRC5), also known as survivin, is a
conserved member of the inhibitor of apoptosis protein (IAPs) family, which is normally …

Positive BCL2L12 expression predicts favorable prognosis in patients with laryngeal squamous cell carcinoma

AI Giotakis, AC Lazaris, A Kataki… - Cancer …, 2019 - journals.sagepub.com
BACKGROUND: Laryngeal squamous cell carcinoma (LSCC) constitutes the third most
frequent head and neck cancer. Several tissue biomarkers have been studied for their …

Quantitative analysis and study of the mRNA expression levels of apoptotic genes BCL2, BAX and BCL2L12 in the articular cartilage of an animal model of …

A Kourtis, PG Adamopoulos, A Papalois… - Annals of …, 2018 - pmc.ncbi.nlm.nih.gov
Background Given that apoptosis of chondrocytes is one of the most important factors
related to the pathogenesis of osteoarthritis (OA), the recent research interest adds progress …

Molecular cloning of novel transcripts of human kallikrein-related peptidases 5, 6, 7, 8 and 9 (KLK5KLK9), using Next-generation sequencing

PG Adamopoulos, CK Kontos, A Scorilas - Scientific Reports, 2017 - nature.com
Alternative splicing of cancer-related genes is a common cellular mechanism accounting for
cancer cell transcriptome complexity and affecting cell cycle control, proliferation, apoptosis …

Alternative Splicing Detection Tool—a novel PERL algorithm for sensitive detection of splicing events, based on next-generation sequencing data analysis

PG Adamopoulos… - Annals of …, 2018 - pmc.ncbi.nlm.nih.gov
Next-generation sequencing (NGS) can provide researchers with high impact information
regarding alternative splice variants or transcript identifications. However, the enormous …