Mitofusin-2 maintains mitochondrial structure and contributes to stress-induced permeability transition in cardiac myocytes
KN Papanicolaou, RJ Khairallah, GA Ngoh… - … and cellular biology, 2011 - Taylor & Francis
Mitofusin-2 (Mfn-2) is a dynamin-like protein that is involved in the rearrangement of the
outer mitochondrial membrane. Research using various experimental systems has shown …
outer mitochondrial membrane. Research using various experimental systems has shown …
Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart
KN Papanicolaou, R Kikuchi, GA Ngoh… - Circulation …, 2012 - Am Heart Assoc
Rationale: At birth, there is a switch from placental to pulmonary circulation and the heart
commences its aerobic metabolism. In cardiac myocytes, this transition is marked by …
commences its aerobic metabolism. In cardiac myocytes, this transition is marked by …
New horizons in the roles and associations of COX-2 and novel natural inhibitors in cardiovascular diseases
W Chen, Y Zhong, N Feng, Z Guo, S Wang, D **ng - Molecular Medicine, 2021 - Springer
Age-related cardiovascular disease is the leading cause of death in elderly populations.
Coxibs, including celecoxib, valdecoxib, etoricoxib, parecoxib, lumiracoxib, and rofecoxib …
Coxibs, including celecoxib, valdecoxib, etoricoxib, parecoxib, lumiracoxib, and rofecoxib …
Cardiomyocyte deletion of mitofusin-1 leads to mitochondrial fragmentation and improves tolerance to ROS-induced mitochondrial dysfunction and cell death
KN Papanicolaou, GA Ngoh… - American Journal …, 2012 - journals.physiology.org
Molecular studies examining the impact of mitochondrial morphology on the mammalian
heart have previously focused on dynamin related protein-1 (Drp-1) and mitofusin-2 (Mfn-2) …
heart have previously focused on dynamin related protein-1 (Drp-1) and mitofusin-2 (Mfn-2) …
Synergistic effects of the GATA-4-mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death
Among the identified microRNAs (miRs) thus far,~ 50% of mammalian miRs are clustered in
the genome and transcribed as polycistronic primary transcripts. However, whether …
the genome and transcribed as polycistronic primary transcripts. However, whether …
Maternal plasma miRNAs expression in preeclamptic pregnancies
H Li, Q Ge, L Guo, Z Lu - BioMed research international, 2013 - Wiley Online Library
Objective. Preeclampsia (PE) is a pregnancy‐specific syndrome and one of the leading
causes of maternal and fetal morbidity and mortality. The pathophysiological mechanisms of …
causes of maternal and fetal morbidity and mortality. The pathophysiological mechanisms of …
Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti …
Background—Cardiovascular side effects associated with cyclooxygenase-2 inhibitor drugs
dominate clinical concern. Cyclooxygenase-2 is expressed in the renal medulla where …
dominate clinical concern. Cyclooxygenase-2 is expressed in the renal medulla where …
LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene expression pattern reveals non-vascular sites of COX-2 expression
There are two schools of thought regarding the cyclooxygenase (COX) isoform active in the
vasculature. Using urinary prostacyclin markers some groups have proposed that vascular …
vasculature. Using urinary prostacyclin markers some groups have proposed that vascular …
Knockout of the Prostaglandin E2 Receptor Subtype 3 Promotes Eccentric Cardiac Hypertrophy and Fibrosis in Mice
S Liu, Y Ji, J Yao, X Zhao, H Xu… - Journal of …, 2017 - journals.sagepub.com
Background: Prostaglandin E2 receptor subtype 3 (EP3), a Gi protein-coupled receptor
activated by prostaglandin E2, plays a particular role in cardioprotection. This study aimed to …
activated by prostaglandin E2, plays a particular role in cardioprotection. This study aimed to …
Deficiency of Capn4 gene inhibits nuclear factor-κB (NF-κB) protein signaling/inflammation and reduces remodeling after myocardial infarction
J Ma, M Wei, Q Wang, J Li, H Wang, W Liu… - Journal of Biological …, 2012 - ASBMB
Calpain has been implicated in acute myocardial injury after myocardial infarction (MI).
However, the causal relationship between calpain and post-MI myocardial remodeling has …
However, the causal relationship between calpain and post-MI myocardial remodeling has …