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Heparin as a therapy for COVID-19: current evidence and future possibilities
Coronavirus disease 2019 (COVID-19), the clinical syndrome associated with infection by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has impacted nearly every …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has impacted nearly every …
[HTML][HTML] The key role of lysosomal protease cathepsins in viral infections
M Scarcella, D d'Angelo, M Ciampa, S Tafuri… - International journal of …, 2022 - mdpi.com
Cathepsins encompass a family of lysosomal proteases that mediate protein degradation
and turnover. Although mainly localized in the endolysosomal compartment, cathepsins are …
and turnover. Although mainly localized in the endolysosomal compartment, cathepsins are …
EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy
Hepatitis C virus (HCV) is a major cause of liver disease, but therapeutic options are limited
and there are no prevention strategies. Viral entry is the first step of infection and requires …
and there are no prevention strategies. Viral entry is the first step of infection and requires …
Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C
JM Pestka, MB Zeisel, E Bläser, P Schürmann… - Proceedings of the …, 2007 - pnas.org
In contrast to a detailed understanding of antiviral cellular immune responses, the impact of
neutralizing antibodies for the resolution of acute hepatitis C is poorly defined. The analysis …
neutralizing antibodies for the resolution of acute hepatitis C is poorly defined. The analysis …
Nucleoside, nucleotide, and non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA-polymerase
Hepatitis C virus (HCV) infection is a global health problem that impacts approximately 180
million individuals. Of those initially infected with HCV approximately 80% will progress to …
million individuals. Of those initially infected with HCV approximately 80% will progress to …
Broad-spectrum antiviral activity of chebulagic acid and punicalagin against viruses that use glycosaminoglycans for entry
Background We previously identified two hydrolyzable tannins, chebulagic acid (CHLA) and
punicalagin (PUG) that blocked herpes simplex virus type 1 (HSV-1) entry and spread …
punicalagin (PUG) that blocked herpes simplex virus type 1 (HSV-1) entry and spread …
[HTML][HTML] Heparan sulfate proteoglycans in viral infection and treatment: a special focus on SARS-CoV-2
Heparan sulfate proteoglycans (HSPGs) encompass a group of glycoproteins composed of
unbranched negatively charged heparan sulfate (HS) chains covalently attached to a core …
unbranched negatively charged heparan sulfate (HS) chains covalently attached to a core …
Apolipoprotein B–dependent hepatitis C virus secretion is inhibited by the grapefruit flavonoid naringenin
Y Nahmias, J Goldwasser, M Casali, D Van Poll… - Hepatology, 2008 - journals.lww.com
Hepatitis C virus (HCV) infects over 3% of the world population and is the leading cause of
chronic liver disease worldwide. HCV has long been known to associate with circulating …
chronic liver disease worldwide. HCV has long been known to associate with circulating …
Glycosaminoglycans in infectious disease
Glycosaminoglycans (GAGs) are complex carbohydrates that are ubiquitously present on
the cell surface and in the extracellular matrix. Interactions between GAGs and pathogens …
the cell surface and in the extracellular matrix. Interactions between GAGs and pathogens …
Heparan sulfate proteoglycans are required for cellular binding of the hepatitis E virus ORF2 capsid protein and for viral infection
The hepatitis E virus (HEV), a nonenveloped RNA virus, is the causative agent of hepatitis E.
The mode by which HEV attaches to and enters into target cells for productive infection …
The mode by which HEV attaches to and enters into target cells for productive infection …