Copper oxide nanoparticles: In vitro and in vivo toxicity, mechanisms of action and factors influencing their toxicology

H Sajjad, A Sajjad, RT Haya, MM Khan, M Zia - … and Physiology Part C …, 2023 - Elsevier
Abstract Copper oxide nanoparticles (CuO NPs) have received increasing interest due to
their distinctive properties, including small particle size, high surface area, and reactivity …

Temperature-induced cardiac remodelling in fish

AN Keen, JM Klaiman, HA Shiels… - Journal of Experimental …, 2017 - journals.biologists.com
Thermal acclimation causes the heart of some fish species to undergo significant
remodelling. This includes changes in electrical activity, energy utilization and structural …

The Frank–Starling mechanism in vertebrate cardiac myocytes

HA Shiels, E White - Journal of Experimental Biology, 2008 - journals.biologists.com
SUMMARY The Frank–Starling law of the heart applies to all classes of vertebrates. It
describes how stretch of cardiac muscle, up to an optimum length, increases contractility …

Adverse outcome pathways for chronic copper toxicity to fish and amphibians

KV Brix, G De Boeck, S Baken… - … toxicology and chemistry, 2022 - academic.oup.com
In the present review, we synthesize information on the mechanisms of chronic copper (Cu)
toxicity using an adverse outcome pathway framework and identify three primary pathways …

The zebrafish heart as a model of mammalian cardiac function

CE Genge, E Lin, L Lee, XY Sheng, K Rayani… - Reviews of Physiology …, 2016 - Springer
Zebrafish (Danio rerio) are widely used as vertebrate model in developmental genetics and
functional genomics as well as in cardiac structure-function studies. The zebrafish heart has …

Tribute to PL Lutz: a message from the heart–why hypoxic bradycardia in fishes?

AP Farrell - Journal of Experimental Biology, 2007 - journals.biologists.com
The sensing and processing of hypoxic signals, the responses to these signals and the
modulation of these responses by other physical and physiological factors are an immense …

What determines systemic blood flow in vertebrates?

W Joyce, T Wang - Journal of Experimental Biology, 2020 - journals.biologists.com
In the 1950s, Arthur C. Guyton removed the heart from its pedestal in cardiovascular
physiology by arguing that cardiac output is primarily regulated by the peripheral …

Avian cardiomyocyte architecture and what it reveals about the evolution of the vertebrate heart

HA Shiels - … Transactions of the Royal Society B, 2022 - royalsocietypublishing.org
Bird cardiomyocytes are long, thin and lack transverse (t)-tubules, which is akin to the
cardiomyocyte morphology of ectothermic non-avian reptiles, who are typified by low …

Nitric oxide improves the hemodynamic performance of the hypoxic goldfish (Carassius auratus) heart

S Imbrogno, C Capria, B Tota, FB Jensen - Nitric Oxide, 2014 - Elsevier
Goldfish tolerate prolonged and severe hypoxia, thus representing a well-suited model to
study the maintenance of cardiac function when O 2 availability represents a limiting factor …

A multi-biomarker approach to assess the sublethal effects of settleable atmospheric particulate matter from an industrial area on Nile tilapia (Oreochromis niloticus)

HA Adorno, I da Costa Souza, MV Monferrán… - Science of The Total …, 2023 - Elsevier
Iron and steel industries discharge a large amount of atmospheric particulate matter (PM)
containing metals and metallic nanoparticles (NPs) that contaminate not only the air, but …