The present review article offers a detailed account of the design strategies employed for the
synthesis of nitrogen-containing anticancer agents. The results of different studies describe …

Coumarin heterocyclic derivatives: chemical synthesis and biological activity - Natural Product
Reports (RSC Publishing) DOI:10.1039/C4NP00162A Royal Society of Chemistry View PDF …

Dual-specificity tyrosine phosphorylation-regulated kinase 1 A (DYRK1A) is a conserved
protein kinase that plays essential roles in various biological processes. It is located in the …

The combination of heterocycles offers a new opportunity to create novel multicyclic
compounds having improved biological activity. Coumarins are ubiquitous natural …

Nitrogen heterocycles are essential parts of the chemical machinery of life and often reveal
intriguing structures. They are not only widespread in terrestrial habitats but can also …

Carbapenems are vital antibiotics, but their efficacy is increasingly compromised by metallo-
β-lactamases (MBLs). Here we report the discovery and optimization of potent broad …

This review article illustrates the growing use of azaindole derivatives as kinase inhibitors
and their contribution to drug discovery and innovation. The different protein kinases which …

In 1985 the first lamellarins were isolated from a small oceanic sea snail. Today, more than
50 lamellarins have been inventoried and numerous derivatives synthesized and tested as …

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a member of an
evolutionarily conserved family of protein kinases that belongs to the CMGC group of …

Protein kinases are one of the most studied drug targets in current pharmacological
research, as evidenced by the vast number of kinase-targeting agents enrolled in active …