Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …

Cellular stress induced by the abnormal accumulation of unfolded or misfolded proteins at
the endoplasmic reticulum (ER) is emerging as a possible driver of human diseases …

Lipid droplets are storage organelles at the centre of lipid and energy homeostasis. They
have a unique architecture consisting of a hydrophobic core of neutral lipids, which is …

Currently, obesity has become a global health issue and is referred to as an epidemic.
Dysfunctional obese adipose tissue plays a pivotal role in the development of insulin …

Triglyceride molecules represent the major form of storage and transport of fatty acids within
cells and in the plasma. The liver is the central organ for fatty acid metabolism. Fatty acids …

The concept of molecular design, integrating diagnostic and therapeutic functions, aligns
with the general trend of modern medical advancement. Herein, we rationally designed the …

Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are the most abundant
phospholipids in all mammalian cell membranes. In the 1950s, Eugene Kennedy and co …

Biological membranes are key elements for the maintenance of cell architecture and
physiology. Beyond a pure barrier separating the inner space of the cell from the outer, the …

Protein-folding stress at the endoplasmic reticulum (ER) is a salient feature of specialized
secretory cells and is also involved in the pathogenesis of many human diseases. ER stress …

In eukaryotic cells, the endoplasmic reticulum is essential for the folding and trafficking of
proteins that enter the secretory pathway. Environmental insults or increased protein …