Cellular responses to widespread DNA replication stress
Replicative DNA polymerases are blocked by nearly all types of DNA damage. The resulting
DNA replication stress threatens genome stability. DNA replication stress is also caused by …
DNA replication stress threatens genome stability. DNA replication stress is also caused by …
TATDN2 resolution of R-loops is required for survival of BRCA1-mutant cancer cells
BRCA1-deficient cells have increased IRE1 RNase, which degrades multiple microRNAs.
Reconstituting expression of one of these, miR-4638–5p, resulted in synthetic lethality in …
Reconstituting expression of one of these, miR-4638–5p, resulted in synthetic lethality in …
Co-evolution of gene transfer agents and their alphaproteobacterial hosts
R Kogay, O Zhaxybayeva - Journal of Bacteriology, 2024 - Am Soc Microbiol
Gene transfer agents (GTAs) are enigmatic elements that resemble small viruses and are
known to be produced during nutritional stress by some bacteria and archaea. The …
known to be produced during nutritional stress by some bacteria and archaea. The …
7-Deazaguanines in DNA: functional and structural elucidation of a DNA modification system
Abstract The modified nucleosides 2′-deoxy-7-cyano-and 2′-deoxy-7-amido-7-
deazaguanosine (dPreQ0 and dADG, respectively) recently discovered in DNA are the …
deazaguanosine (dPreQ0 and dADG, respectively) recently discovered in DNA are the …
The F plasmid conjutome: the repertoire of E. coli proteins translocated through an F-encoded type IV secretion system
Bacterial conjugation systems pose a major threat to human health through their widespread
dissemination of mobile genetic elements (MGEs) carrying cargoes of antibiotic resistance …
dissemination of mobile genetic elements (MGEs) carrying cargoes of antibiotic resistance …
The TatD-like DNase of Plasmodium is a virulence factor and a potential malaria vaccine candidate
Z Chang, N Jiang, Y Zhang, H Lu, J Yin… - Nature …, 2016 - nature.com
Neutrophil extracellular traps (NETs), composed primarily of DNA and proteases, are
released from activated neutrophils and contribute to the innate immune response by …
released from activated neutrophils and contribute to the innate immune response by …
Molecular mechanism of engineered Zymomonas mobilis to furfural and acetic acid stress
S Shabbir, W Wang, M Nawaz, P Boruah… - Microbial Cell …, 2023 - Springer
Acetic acid and furfural (AF) are two major inhibitors of microorganisms during
lignocellulosic ethanol production. In our previous study, we successfully engineered …
lignocellulosic ethanol production. In our previous study, we successfully engineered …
Human and bacterial TatD enzymes exhibit apurinic/apyrimidinic (AP) endonuclease activity
J Dorival, BF Eichman - Nucleic Acids Research, 2023 - academic.oup.com
TatD enzymes are evolutionarily conserved deoxyribonucleases associated with DNA
repair, apoptosis, development, and parasite virulence. Three TatD paralogs exist in …
repair, apoptosis, development, and parasite virulence. Three TatD paralogs exist in …
iTRAQ-based global proteomic analysis of Salmonella enterica serovar Typhimurium in response to desiccation, low water activity, and thermal treatment
In this study, the changes in the global proteome of Salmonella in response to desiccation
and thermal treatment were investigated by using an iTRAQ multiplex technique. A …
and thermal treatment were investigated by using an iTRAQ multiplex technique. A …
TatD DNases Contribute to Biofilm Formation and Virulence in Trueperella pyogenes
Z Zhang, Y Liang, L Yu, M Chen, Y Guo… - Frontiers in …, 2021 - frontiersin.org
TatD DNases are conserved proteins in a variety of organisms and are considered potential
virulence factors in Plasmodium falciparum and Streptococcus pneumoniae. However, the …
virulence factors in Plasmodium falciparum and Streptococcus pneumoniae. However, the …