The traditional two-dimensional (2D) in vitro cell culture system (on a flat support) has long
been used in cancer research. However, this system cannot be fully translated into clinical …

The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

The increasingly intimate bond connecting soft actuation devices and emerging biomedical
applications is triggering the development of novel materials with superb biocompatibility …

Active biomaterials offer novel approaches to study mechanotransduction in mammalian
cells. These material systems probe cellular responses by dynamically modulating their …

Cell culture is an indispensable in vitro tool used to improve our perception and
understanding of cell biology, the development of tissue engineering, tissue morphology …

Cells in vivo reside within complex microenvironments composed of both biochemical and
biophysical cues. The dynamic feedback between cells and their microenvironments hinges …

Mechanobiology-on-a-chip is a growing field focusing on how mechanical inputs modulate
physico-chemical output in microphysiological systems. It is well known that biomechanical …

This study aimed to determine the effect of the structural properties of acetylated bacterial
cellulose (ABC) on its in vitro biological performance. Acetylation resulted in several …

The tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) is
characterized by deposition of desmoplastic matrix (including collagen and hyaluronic acid) …

Introduction Periodontitis is a chronic infectious disease and is the major cause of tooth loss
and other oral health issues around the world. Periodontal tissue regeneration has therefore …