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Insights on the mechanism of bleomycin to induce lung injury and associated in vivo models: a review
Acute lung injury leads to the development of chronic conditions such as idiopathic
pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), asthma as well as …
pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), asthma as well as …
Lung regeneration: diverse cell types and the therapeutic potential
Lung tissue has a certain regenerative ability and triggers repair procedures after injury.
Under controllable conditions, lung tissue can restore normal structure and function …
Under controllable conditions, lung tissue can restore normal structure and function …
Mitochondria‐Targeted Nanoadjuvants Induced Multi‐Functional Immune‐Microenvironment Remodeling to Sensitize Tumor Radio‐Immunotherapy
Z Zhou, C Li, C Li, L Zhou, S Tan, W Hou… - Advanced …, 2024 - Wiley Online Library
It is newly revealed that collagen works as a physical barrier to tumor immune infiltration,
oxygen perfusion, and immune depressor in solid tumors. Meanwhile, after radiotherapy …
oxygen perfusion, and immune depressor in solid tumors. Meanwhile, after radiotherapy …
OGG1 and MUTYH repair activities promote telomeric 8-oxoguanine induced senescence in human fibroblasts
M De Rosa, RP Barnes, AC Detwiler… - Nature …, 2025 - nature.com
Telomeres are hypersensitive to the formation of the common oxidative lesion 8-oxoguanine
(8oxoG), which impacts telomere stability and function. OGG1 and MUTYH glycosylases …
(8oxoG), which impacts telomere stability and function. OGG1 and MUTYH glycosylases …
OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage
Y Zhong, X Zhang, R Feng, Y Fan… - Medicinal Research …, 2024 - Wiley Online Library
Oxidative DNA damage‐related diseases, such as incurable inflammation, malignant
tumors, and age‐related disorders, present significant challenges in modern medicine due …
tumors, and age‐related disorders, present significant challenges in modern medicine due …
[HTML][HTML] Nebulized inhalation of nintedanib-loaded biomimetic nano-liposomes attenuated bleomycin-induced interstitial lung fibrosis in mice
L Rao, P Zhu, M Guo, M Hu, X Guo, Y Du, G Xu - Nano Today, 2024 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is an irreversible interstitial lung disease with a poor
prognosis. However, there are currently few drugs available for its treatment. Nintedanib is …
prognosis. However, there are currently few drugs available for its treatment. Nintedanib is …
[HTML][HTML] The role of DNA and RNA guanosine oxidation in cardiovascular diseases
Y Li, X Wang - Pharmacological research, 2024 - Elsevier
Cardiovascular diseases (CVD) persist as a prominent cause of mortality worldwide, with
oxidative stress constituting a pivotal contributory element. The oxidative modification of …
oxidative stress constituting a pivotal contributory element. The oxidative modification of …
[HTML][HTML] Elamipretide (SS-31) attenuates idiopathic pulmonary fibrosis by inhibiting the nrf2-dependent NLRP3 inflammasome in macrophages
Y Nie, J Li, X Zhai, Z Wang, J Wang, Y Wu, P Zhao… - Antioxidants, 2023 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a progressive fatal lung disease with a limited
therapeutic strategy. Mitochondrial oxidative stress in macrophages is directly linked to IPF …
therapeutic strategy. Mitochondrial oxidative stress in macrophages is directly linked to IPF …
[HTML][HTML] Amelioration of pulmonary fibrosis by matrix metalloproteinase-2 overexpression
R Inoue, T Yasuma, V Fridman D'Alessandro… - International Journal of …, 2023 - mdpi.com
Idiopathic pulmonary fibrosis is a progressive and fatal disease with a poor prognosis. Matrix
metalloproteinase-2 is involved in the pathogenesis of organ fibrosis. The role of matrix …
metalloproteinase-2 is involved in the pathogenesis of organ fibrosis. The role of matrix …
A branched polymer-based agent for efficient and precise targeting of fibrosis diseases by magnetic resonance imaging
X Wang, J Chen, Z Li, Y Li, Y Zhang, Q Gong… - Journal of Controlled …, 2024 - Elsevier
Herein, we synthesized and characterized gadolinium-based hyperbranched polymers,
POADGd and PODGd, through RAFT polymerization as magnetic resonance imaging (MRI) …
POADGd and PODGd, through RAFT polymerization as magnetic resonance imaging (MRI) …