Lamins are intermediate filament proteins that form a scaffold, termed nuclear lamina, at the
nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm …

The engineering of 3-dimensional (3D) heart muscles has undergone exciting progress for
the past decade. Profound advances in human stem cell biology and technology, tissue …

Mutations in lamins, which are ubiquitous nuclear intermediate filaments, lead to a variety of
disorders including muscular dystrophy and dilated cardiomyopathy. Lamins provide …

Inflammasomes are critical sensors that convey cellular stress and pathogen presence to the
immune system by activating inflammatory caspases and cytokines such as IL-1β. The …

The nuclear lamins are polymeric intermediate filament proteins that scaffold the nucleus
and organize the genome in nearly all eukaryotic cells. This review focuses on the dynamic …

In the cell, the proteasome and lysosomes represent the most important proteolytic
machineries, responsible for the protein degradation in the ubiquitin–proteasome system …

Mutations in the gene for lamin A/C (LMNA) cause a diverse range of diseases known as
laminopathies. LMNA-related cardiomyopathy is a common inherited heart disease and is …

The nuclear lamina (NL) is a structural component of the nuclear envelope and makes
extensive contacts with integral nuclear membrane proteins and chromatin. These …

Background—Heterozygous mutations in sarcomere genes in hypertrophic cardiomyopathy
(HCM) are proposed to exert their effect through gain of function for missense mutations or …

The nuclear lamina is a critical structural domain for the maintenance of genomic stability
and whole-cell mechanics. Mutations in the LMNA gene, which encodes nuclear A-type …