Insights into recent findings and clinical application of YAP and TAZ in cancer
Decades of research have mapped out the basic mechanics of the Hippo pathway. The
paralogues Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding …
paralogues Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding …
The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer
R Cunningham, CG Hansen - Clinical Science, 2022 - portlandpress.com
Tumorigenesis is a highly complex process, involving many interrelated and cross-acting
signalling pathways. One such pathway that has garnered much attention in the field of …
signalling pathways. One such pathway that has garnered much attention in the field of …
[HTML][HTML] Temporal evolution reveals bifurcated lineages in aggressive neuroendocrine small cell prostate cancer trans-differentiation
CC Chen, W Tran, K Song, T Sugimoto, MB Obusan… - Cancer Cell, 2023 - cell.com
Trans-differentiation from an adenocarcinoma to a small cell neuroendocrine state is
associated with therapy resistance in multiple cancer types. To gain insight into the …
associated with therapy resistance in multiple cancer types. To gain insight into the …
Regulation of CEACAM5 and therapeutic efficacy of an anti-CEACAM5–SN38 antibody–drug conjugate in neuroendocrine prostate cancer
DC DeLucia, TM Cardillo, L Ang, MP Labrecque… - Clinical Cancer …, 2021 - AACR
Purpose: Neuroendocrine prostate cancer (NEPC) is an aggressive form of castration-
resistant prostate cancer (CRPC) for which effective therapies are lacking. We previously …
resistant prostate cancer (CRPC) for which effective therapies are lacking. We previously …
Wnt/β-catenin signal transduction pathway in prostate cancer and associated drug resistance
C Wang, Q Chen, H Xu - Discover Oncology, 2021 - Springer
Globally, prostate cancer ranks second in cancer burden of the men. It occurs more
frequently in black men compared to white or Asian men. Usually, high rates exist for men …
frequently in black men compared to white or Asian men. Usually, high rates exist for men …
CYLD regulates cell ferroptosis through Hippo/YAP signaling in prostate cancer progression
Y Gu, S Wu, J Fan, Z Meng, G Gao, T Liu, Q Wang… - Cell Death & …, 2024 - nature.com
Prostate cancer (PCa) is one of the most common malignancy in men. However, the
molecular mechanism of its pathogenesis has not yet been elucidated. In this study, we …
molecular mechanism of its pathogenesis has not yet been elucidated. In this study, we …
WNT5a signaling through ROR2 activates the hippo pathway to suppress YAP1 activity and tumor growth
Noncanonical Wnt signaling by WNT5a has oncogenic and tumor suppressive activities, but
downstream pathways mediating these specific effects remain to be fully established. In a …
downstream pathways mediating these specific effects remain to be fully established. In a …
[HTML][HTML] Resistance to androgen receptor signaling inhibition does not necessitate development of neuroendocrine prostate cancer
Resistance to AR signaling inhibitors (ARSis) in a subset of metastatic castration-resistant
prostate cancers (mCRPCs) occurs with the emergence of AR–neuroendocrine prostate …
prostate cancers (mCRPCs) occurs with the emergence of AR–neuroendocrine prostate …
YAP1 and WWTR1 expression inversely correlates with neuroendocrine markers in Merkel cell carcinoma
Background Merkel cell carcinoma (MCC) is an aggressive neuroendocrine (NE) skin
cancer caused by severe UV-induced mutations or expression of Merkel cell polyomavirus …
cancer caused by severe UV-induced mutations or expression of Merkel cell polyomavirus …
Novel insights in cell cycle dysregulation during prostate cancer progression
Prostate cancer (CaP) remains the second leading cause of cancer deaths in Western men.
These deaths occur because metastatic CaP acquires resistance to available treatments …
These deaths occur because metastatic CaP acquires resistance to available treatments …