Bipolar disorders (BDs) are recurrent and sometimes chronic disorders of mood that affect
around 2% of the world's population and encompass a spectrum between severe elevated …

This review summarizes the last decade of work by the ENIGMA (E nhancing N euro I
maging G enetics through M eta A nalysis) Consortium, a global alliance of over 1400 …

Bipolar disorder is heterogeneous in phenomenology, illness trajectory, and response to
treatment. Despite evidence for the efficacy of multimodality interventions, the majority of …

Observational studies have reported the correlations between brain imaging-derived
phenotypes (IDPs) and psychiatric disorders; however, whether the relationships are causal …

The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly
understood, and reported disease effects on the brain vary widely between studies. In an …

Background Neuroimaging studies have shown structural alterations in several brain
regions in children and adults with attention deficit hyperactivity disorder (ADHD). Through …

We report results from the Bipolar Exome (BipEx) collaboration analysis of whole-exome
sequencing of 13,933 patients with bipolar disorder (BD) matched with 14,422 controls. We …

Identifying brain alterations that contribute to suicidal thoughts and behaviors (STBs) are
important to develop more targeted and effective strategies to prevent suicide. In the last …

Despite decades of research, the pathophysiology of bipolar disorder (BD) is still not well
understood. Structural brain differences have been associated with BD, but results from …

Progressive functional decline in the epilepsies is largely unexplained. We formed the
ENIGMA-Epilepsy consortium to understand factors that influence brain measures in …