Cadmium (Cd) is a toxic metal for the human organism and for all ecosystems. Cd is
naturally found at low levels; however, higher amounts of Cd in the environment result from …

Unlike other essential trace elements that interact with proteins in the form of cofactors,
selenium (Se) becomes co-translationally incorporated into the polypeptide chain as part of …

Although the neurogenesis-enhancing effects of exercise have been extensively studied, the
molecular mechanisms underlying this response remain unclear. Here, we propose that this …

Ferroptosis is an iron-and lipid peroxidation-dependent cell death modality and emerging
evidence indicates that ferroptosis has great explanatory potential for neuronal loss and …

Ischemic cerebral stroke is a major cause of death and morbidity. Currently, no
neuroprotective agents have been shown to impact the clinical outcomes in cerebral stroke …

Abstract Purpose of Review Selenium, a trace element, is ubiquitous in the environment.
The main source of human exposure is diet. Despite its nutritional benefits, it is one of the …

This article provides an overview of the background knowledge of ferroptosis in the nervous
system, as well as the key role of nuclear factor E2-related factor 2 (Nrf2) in regulating …

Abstract Glutathione peroxidase 4 (GPx4) is an antioxidant enzyme reported as an inhibitor
of ferroptosis, a recently discovered non-apoptotic form of cell death. This pathway was …

Selenium (Se) is one of the essential trace elements that plays a biological role in the body,
mainly in the form of selenoproteins. Selenoproteins can be involved in the regulation of …

Iron accumulation is a cardinal feature of degenerating regions in the Parkinson's disease
brain. As a potent pro-oxidant, redox-active iron may be a key player in upstream …