The extracellular matrix regulates tissue development and homeostasis, and its
dysregulation contributes to neoplastic progression. The extracellular matrix serves not only …

Transitions between epithelial and mesenchymal phenotypes–the epithelial to
mesenchymal transition (EMT) and its reverse the mesenchymal to epithelial transition …

Tissues stiffen during aging and during the pathological progression of cancer, fibrosis, and
cardiovascular disease. Extracellular matrix stiffness is emerging as a prominent mechanical …

Metastasis is the leading cause of cancer mortality. The metastatic cascade represents a
multi-step process which includes local tumor cell invasion, entry into the vasculature …

The cytoskeleton of animal cells is one of the most complicated and functionally versatile
structures, involved in processes such as endocytosis, cell division, intra-cellular transport …

The DEAD-box helicase family member DDX3X (DBX, DDX3) functions in nearly all stages
of RNA metabolism and participates in the progression of many diseases, including virus …

Collective cell migration results from the establishment and maintenance of collective
polarization, mechanocoupling, and cytoskeletal kinetics. The guidance of collective cell …

Acute lymphoblastic leukaemia (ALL) has a marked propensity to metastasize to the central
nervous system (CNS). In contrast to brain metastases from solid tumours, metastases of …

Breast cancer (BC) is mostly observed in women and is responsible for huge mortality in
women subjects globally. Due to the continued development of drug resistance and other …

Organ-specific metastasis is the primary cause of cancer patient death. The distant
metastasis of tumor cells to specific organs depends on both the intrinsic characteristics of …