Osteoarthritis (OA) is the most common form of arthritis. It is characterized by progressive
destruction of articular cartilage and the development of chronic pain and constitutes a …

It is more than 50years since the lysosome was discovered. Since then its hydrolytic
machinery, including proteases and other hydrolases, has been fairly well identified and …

It is widely accepted that metastasis is a late event in cancer progression. Here, however, we
show that tumor cells can disseminate systemically from earliest epithelial alterations in HER …

Previous work has shown that cisplatin (CDDP) becomes concentrated in lysosomes, and
that acquired resistance to CDDP is associated with abnormalities of protein trafficking and …

Tumors develop through successive stages characterized by changes in gene expression
and protein function. Gene expression profiling of pancreatic islet tumors in a mouse model …

It is now generally accepted that aging and eventual death of multicellular organisms is to a
large extent related to macromolecular damage by mitochondrially produced reactive …

The vacuolar ATPases (V-ATPases) are a family of proton pumps that couple ATP hydrolysis
to proton transport into intracellular compartments and across the plasma membrane. They …

Multiple types of degradative enzymes, including cathepsins of the cysteine protease family,
have been implicated in the regulation of angiogenesis and invasion during cancer …

The general view on cysteine cathepsins, which were long believed to be primarily involved
in intracellular protein turnover, has dramatically changed in last 10 to 15 years. The …

Cysteine cathepsins are a family of lysosomal proteases that are often upregulated in
various human cancers, and have been implicated in distinct tumorigenic processes such as …