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Performance, personality, and energetics: correlation, causation, and mechanism
The study of phenotypic evolution should be an integrative endeavor that combines different
approaches and crosses disciplinary and phylogenetic boundaries to consider complex …
approaches and crosses disciplinary and phylogenetic boundaries to consider complex …
The biological control of voluntary exercise, spontaneous physical activity and daily energy expenditure in relation to obesity: human and rodent perspectives
Mammals expend energy in many ways, including basic cellular maintenance and repair,
digestion, thermoregulation, locomotion, growth and reproduction. These processes can …
digestion, thermoregulation, locomotion, growth and reproduction. These processes can …
Measuring behavioral and endocrine responses to novelty stress in adult zebrafish
Several behavioral assays are currently used for high-throughput neurophenoty** and
screening of genetic mutations and psychotropic drugs in zebrafish (Danio rerio). In this …
screening of genetic mutations and psychotropic drugs in zebrafish (Danio rerio). In this …
The use of a running wheel to measure activity in rodents: relationship to energy balance, general activity, and reward
Running wheels are commonly employed to measure rodent physical activity in a variety of
contexts, including studies of energy balance and obesity. There is no consensus on the …
contexts, including studies of energy balance and obesity. There is no consensus on the …
Physical exercise improves brain cortex and cerebellum mitochondrial bioenergetics and alters apoptotic, dynamic and auto (mito) phagy markers
We here investigate the effects of two exercise modalities (endurance treadmill training-TM
and voluntary free-wheel activity-FW) on the brain cortex and cerebellum mitochondrial …
and voluntary free-wheel activity-FW) on the brain cortex and cerebellum mitochondrial …
Neurobiology of mice selected for high voluntary wheel-running activity
Selective breeding of house mice has been used to study the evolution of locomotor
behavior. Our model consists of 4 replicate lines selectively bred for high voluntary wheel …
behavior. Our model consists of 4 replicate lines selectively bred for high voluntary wheel …
Neurobiological studies of fatigue
Fatigue is a symptom associated with many disorders, is especially common in women and
in older adults, and can have a huge negative influence on quality of life. Although most past …
in older adults, and can have a huge negative influence on quality of life. Although most past …
Lifelong voluntary exercise in the mouse prevents age-related alterations in gene expression in the heart
We present the first quantitative gene expression analysis of cardiac aging under conditions
of sedentary and active lifestyles using high-density oligonucleotide arrays representing …
of sedentary and active lifestyles using high-density oligonucleotide arrays representing …
Does behavior evolve first? Correlated responses to selection for voluntary wheel-running behavior in house mice
How traits at multiple levels of biological organization evolve in a correlated fashion in
response to directional selection is poorly understood, but two popular models are the very …
response to directional selection is poorly understood, but two popular models are the very …
209. Correction of Hunter Syndrome in the MPSII Mouse Model by AAV2/8-Mediated Gene Delivery
Mucopolysaccharidosis type II (MPSII; Hunter syndrome) is a lysosomal storage disorder
caused by a deficiency in the enzyme iduronate 2-sulfatase. At present, the therapeutic …
caused by a deficiency in the enzyme iduronate 2-sulfatase. At present, the therapeutic …