Lysosomal storage diseases represent a group of about 50 genetic disorders caused by
deficiencies of lysosomal and non-lysosomal proteins. Patients accumulate compounds …

Oligodendrocytes (OLs) are mature glial cells that myelinate axons in the brain and spinal
cord. As such, they are integral to functional and efficient neuronal signaling. The embryonic …

Objective Gaucher disease (GD) is a lysosomal storage disease characterized by a
deficiency of glucocerebrosidase. Although enzyme‐replacement and substrate‐reduction …

Since the discovery of the lysosome in 1955, advances have been made in understanding
the key roles and functions of this organelle. The concept of lysosomal storage diseases …

Neuroinflammation is a host defense mechanism associated with neutralization of an insult
and restoration of normal structure and function of brain. Neuroinflammation is a hallmark of …

Experimental autoimmune encephalomyelitis (EAE) is a T cell-mediated autoimmune
disease of the CNS. Metformin is the most widely used drug for diabetes and mediates its …

Ovarian cancer (OvCa) is the fifth most common cause of death from all cancers among
women in United Sates and the leading cause of death from gynecological malignancies …

The challenges in the diagnosis, prognosis, and monitoring of Gaucher disease (GD), an
autosomal recessive inborn error of glycosphingolipid metabolism, can negatively impact …

With a constitutive recycling function and the capacity to digest exogenous material as well
as endogenous organelles in the process of autophagy, lysosomes are at the heart of the …

Metabolism and energy processes governing oligodendrocyte function during
neuroinflammatory disease are of great interest. However, how varied cellular environments …