Mass spectrometry-based proteomic technology and its application to study skeletal muscle cell biology

P Dowling, D Swandulla, K Ohlendieck - Cells, 2023 - mdpi.com
Voluntary striated muscles are characterized by a highly complex and dynamic proteome
that efficiently adapts to changed physiological demands or alters considerably during …

Ubiquitylomics: An Emerging Approach for Profiling Protein Ubiquitylation in Skeletal Muscle

SO Lord, HE Johnston, RS Samant… - Journal of cachexia …, 2024 - Wiley Online Library
Skeletal muscle is a highly adaptable tissue, finely tuned by various physiological and
pathological factors. Whilst the pivotal role of skeletal muscle in overall health is widely …

[HTML][HTML] A Scaled Proteomic Discovery Study for Prostate Cancer Diagnostic Markers Using ProteographTM and Trapped Ion Mobility Mass Spectrometry

MEK Chang, J Lange, JM Cartier, TW Moore… - International journal of …, 2024 - mdpi.com
There is a significant unmet need for clinical reflex tests that increase the specificity of
prostate-specific antigen blood testing, the longstanding but imperfect tool for prostate …

The expanding roles of myonuclei in adult skeletal muscle health and function

AK Borowik, KA Murach, BF Miller - Biochemical Society …, 2024 - portlandpress.com
Skeletal muscle cells (myofibers) require multiple nuclei to support a cytoplasmic volume
that is larger than other mononuclear cell types. It is dogmatic that mammalian resident …

Muscle fiber proteomics reveals sex-and fiber type-specific adaptations to resistance training

L Moesgaard, R Moreno-Justicia, J Schmalbruch… - bioRxiv, 2024 - biorxiv.org
Skeletal muscle hypertrophy is a hallmark of resistance training that positively impacts
health and longevity. However, despite physiological differences between sexes and fiber …

The effect of unaffected side resistance training on upper limb function reconstruction and prevention of sarcopenia in stroke patients: a randomized controlled trial

T Feng, C Zhao, J Dong, Z Xue, F Cai, X Li, Z Hu… - Scientific Reports, 2024 - nature.com
Aging has made stroke a top killer and disabler, with post-stroke sarcopenia worsening
disability and quality of life. While resistance training benefits the elderly, its impact on stroke …

Comparative analysis of acute eccentric contraction-induced changes to the skeletal muscle transcriptome in young and aged mice and humans

JR Boykin, JL Steiner, GR Laskin… - American Journal …, 2025 - journals.physiology.org
Adaptations to skeletal muscle following resistance exercise are due in part to changes to
the skeletal muscle transcriptome. Although transcriptional changes in response to …

[HTML][HTML] Acute and Chronic Resistance Training, Acute Endurance Exercise, nor Physiologically Plausible Lactate In Vitro Affect Skeletal Muscle Lactylation

ML Mattingly, DA Anglin, BA Ruple… - International Journal of …, 2024 - mdpi.com
We examined changes in skeletal muscle protein lactylation and acetylation in response to
acute resistance exercise, chronic resistance training (RT), and a single endurance cycling …

Skeletal muscle ribosome analysis: A comparison of common assay methods and utilization of a novel RiboAb antibody cocktail

JS Godwin, JM Michel, CB Mobley… - Physiological …, 2025 - Wiley Online Library
While total RNA concentrations putatively represent ribosome content, there is a need to
homologize various quantification approaches. Thus, total RNA concentrations ([RNA]) …

The effects of resistance training on denervated myofibers, senescent cells, and associated protein markers in middle-aged adults

BA Ruple, ML Mattingly, JS Godwin, MC McIntosh… - bioRxiv, 2023 - biorxiv.org
Denervated myofibers and senescent cells are hallmarks of skeletal muscle aging. However,
sparse research has examined how resistance training affects these outcomes. We …