Gas vesicles are gas‐filled protein structures increasing the buoyancy of cells. The gas
vesicle envelope is mainly constituted by the 8 kDa protein GvpA forming a wall with a water …

The objectives of this study include the design of a series of novel fullerene-based inhibitors
for HIV-1 protease (HIV-1 PR), by employing two strategies that can also be applied to the …

In the infected cell, HIV-1 protease (PR) is initially synthesized as part of the GagPol
polyprotein. PR autoprocessing is a virus-specific process by which the PR domain …

Amino acids committed to a particular function correlate tightly along evolution and tend to
form clusters in the 3D structure of the protein. Consequently, a protein can be seen as a …

We developed an in silico mechanical model to analyze the process of cAMP-induced
conformational modulations in hyperpolarization-activated cyclic nucleotide-gated (HCN) …

The proper biological functioning of proteins often relies on the occurrence of coordinated
fluctuations around their native structure, or on their ability to perform wider and sometimes …

Chlorella viruses have icosahedral capsids with an internal membrane enclosing their large
dsDNA genomes and associated proteins. Their genomes are packaged in the particles with …

We have designed and synthesized new molecular tongs based on a rigid naphthalene
scaffold and evaluated their antidimer activity on HIV-1 protease (PR). We inserted …

Mutual information (MI) is a standard measure in information theory to observe and quantify
correlated signals and events in both, empirical data sets and theoretical models. In the field …

The small viral channel Kcv is a Kir-like K+ channel of only 94 amino acids. With this simple
structure, the tetramer of Kcv represents the pore module of all complex K+ channels. To …