Chitosan/solid-lipid nanoparticles hybrid gels for vaginal delivery of estradiol for management of vaginal menopausal symptoms

HA Abou-Taleb, Z Fathalla, DM Naguib, AA Fatease… - Pharmaceuticals, 2023 - mdpi.com
Hormonal replacement therapy is the mainstay treatment to improve quality of life and
reduce mortality. With the increasing number of young women with early menopause …

Repaglinide–Solid Lipid Nanoparticles in Chitosan Patches for Transdermal Application: Box–Behnken Design, Characterization, and In Vivo Evaluation

HSM Ali, N Namazi, HM Elbadawy… - International Journal …, 2024 - Taylor & Francis
Background Repaglinide (REP) is an antidiabetic drug with limited oral bioavailability
attributable to its low solubility and considerable first-pass hepatic breakdown. This study …

Platelet directed lectin-conjugated lipid nanocarriers for ticagrelor oral delivery: Development and Evaluation

MN Abdel-Azeem, MI Mohamed, MA Akl - Journal of Drug Delivery Science …, 2024 - Elsevier
Oral delivery of biopharmaceutical classified IV drugs has a great challenge despite the
most convenient route of drug administration. Ticagrelor hydrophobicity properties and non …

Development of solid lipid nanoparticles as dry powder: characterization and formulation considerations

D Santonocito, MG Sarpietro, F Castelli, MR Lauro… - Molecules, 2023 - mdpi.com
Solid lipid nanoparticles (SLNs) are lipid-based colloidal systems used for the delivery of
active compounds. Although SLNs have many benefits, they show important issues due to …

Preparation and Characterization of Nanostructured Lipid Carriers (NLCs) Containing Glycyrrhiza glabra Extract for the Treatment of Skin Hyperpigmentation

A Hoseinsalari, H Atapour-Mashhad… - Current …, 2024 - benthamdirect.com
Purpose This study aimed to prepare, characterize, and in vitro and in vivo evaluate a novel
nanostructured lipid carriers (NLCs) formulation containing two fractions of Glycyrrhiza …

Signal mining and risk analysis of Alprazolam adverse events based on the FAERS database

F Huang, X San, Q Liu, H Zhu, W Xu - Scientific Reports, 2024 - nature.com
This study aims to evaluate the safety of Alprazolam by analyzing the FAERS database,
provide data analysis for monitoring adverse drug reactions. This research encompasses …

Nose to brain delivery of escitalopram-loaded nano-structured lipid carriers thermosensitive gel: Formulation, physiochemical, pharmacokinetic and …

M Jawad, U Shafique, F ud Din, A Butt, S Khan… - Journal of Drug Delivery …, 2024 - Elsevier
The primary focus of the undertaken research was to design and develop poloxamer-based
thermosensitive gel system of escitalopram-loaded nano-structured lipid carriers (ESC …

Topical system of Chitosan based hydrogel fabricated with fusidic acid loaded SLNs: A new approach against MRSA related wound infections

BA Shah, S uz Zaman, A Zeb, N Ullah… - Journal of Drug Delivery …, 2025 - Elsevier
This research work aims to explore the potential therapeutic efficacy of Fusidic acid loaded
solid lipid nanoparticles (FA-SLNs) based hydrogel for topical delivery, particularly focusing …

Nanoencapsulation of Vitamin B12 with Opuntia ficus-indica seed oil for food supplements uses

RM Ferreira, A Granja, AMS Silva, JA Saraiva… - Food and Bioproducts …, 2025 - Elsevier
This study addressed the nutritional challenges faced by vegetarians and vegans,
emphasizing the limited access to essential nutrients like vitamin B12 found mainly in animal …

Nebulized, macrophage-targeted, Linezolid-loaded lipid carriers for intracellular treatment of tubercular infections–In vitro/in vivo study

S Makled, N Nafee, H Okasha, N Boraie - Journal of Drug Delivery Science …, 2024 - Elsevier
Effective treatment of tuberculosis (TB) demands progression control in line with TB
elimination. The objective herein is to formulate nebulized targeted antitubercular-lipid …