Repairing gut barrier by traditional Chinese medicine: roles of gut microbiota

Y Zhou, D Zhang, H Cheng, J Wu, J Liu… - Frontiers in cellular …, 2024 - frontiersin.org
Gut barrier is not only part of the digestive organ but also an important immunological organ
for the hosts. The disruption of gut barrier can lead to various diseases such as obesity and …

Breaking the barrier: The role of gut epithelial permeability in the pathogenesis of hypertension

M Snelson, T Vanuytsel, FZ Marques - Current Hypertension Reports, 2024 - Springer
Abstract Purpose of the Review To review what intestinal permeability is and how it is
measured, and to summarise the current evidence linking altered intestinal permeability with …

Binding of Akkermansia muciniphila to mucin is O-glycan specific

J Elzinga, Y Narimatsu, N de Haan, H Clausen… - Nature …, 2024 - nature.com
The intestinal anaerobic bacterium Akkermansia muciniphila is specialized in the
degradation of mucins, which are heavily O-glycosylated proteins that constitute the major …

Diet-driven differential response of Akkermansia muciniphila modulates pathogen susceptibility

M Wolter, ET Grant, M Boudaud, NA Pudlo… - Molecular systems …, 2024 - embopress.org
The erosion of the colonic mucus layer by a dietary fiber-deprived gut microbiota results in
heightened susceptibility to an attaching and effacing pathogen, Citrobacter rodentium …

A bacterial sialidase mediates early-life colonization by a pioneering gut commensal

E Buzun, CY Hsu, K Sejane, RE Oles, AV Ayala… - Cell Host & Microbe, 2024 - cell.com
The early microbial colonization of the gastrointestinal tract can have long-term impacts on
development and health. Keystone species, including Bacteroides spp., are prominent in …

Intestinal changes in permeability, tight junction and mucin synthesis in a mouse model of Alzheimer's disease

J He, Y Liu, J Li, Y Zhao, H Jiang… - International …, 2023 - spandidos-publications.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the
accumulation of amyloid-β (Aβ) in the brain. The gut/brain axis may serve a role in AD …

Mutant glycosidases for labeling sialoglycans with high specificity and affinity

S Liang, Q Tang, X Guo, Z Li, Y Guo, J Chang… - Nature …, 2025 - nature.com
Affinity labeling of biomacromolecules is vital for bioimaging and functional studies.
However, affinity probes recognizing glycans with high specificity remain scarce. Here we …

Lactate protects intestinal epithelial barrier function from dextran sulfate sodium-induced damage by GPR81 signaling

X Li, Z Yao, J Qian, H Li, H Li - Nutrients, 2024 - mdpi.com
The dysregulation of the intestinal epithelial barrier significantly contributes to the
inflammatory progression of ulcerative colitis. Recent studies have indicated that lactate …

Host–pathobiont interactions in Crohn's disease

R Caruso, BC Lo, GY Chen, G Núñez - … Reviews Gastroenterology & …, 2024 - nature.com
The mammalian intestine is colonized by trillions of microorganisms that are collectively
referred to as the gut microbiota. The majority of symbionts have co-evolved with their host in …

[HTML][HTML] The underrated gut microbiota helminths, bacteriophages, fungi, and archaea

MJ Garcia-Bonete, A Rajan, F Suriano, E Layunta - Life, 2023 - mdpi.com
The microbiota inhabits the gastrointestinal tract, providing essential capacities to the host.
The microbiota is a crucial factor in intestinal health and regulates intestinal physiology …