Cytosolic Ca 2+ concentration levels fluctuate in an ordered manner along the cell cycle, in
line with the fact that Ca 2+ is involved in the regulation of cell proliferation. Cell proliferation …

RAD21 (also known as KIAA0078, NXP1, HR21, Mcd1, Scc1, and hereafter called RAD21),
an essential gene, encodes a DNA double-strand break (DSB) repair protein that is …

Calpains are Ca2+-dependent intracellular proteases. We show here that calpain-generated
natural C-terminal fragments of proteins that include G protein–coupled receptors …

Ability to reproduce is one of the hallmark features of all life forms by which new organisms
are produced from their progenitors. During this process each cell duplicates its genome …

Background Cohesin is a chromosome-associated SMC–kleisin complex that mediates
sister chromatid cohesion, recombination, and most chromosomal processes during mitosis …

Calpains are intracellular Ca2+-dependent Cys proteases that play important roles in a wide
range of biological phenomena via the limited proteolysis of their substrates. Genetic defects …

The cohesin complex is responsible for the fidelity of chromosomal segregation during
mitosis. It consists of four core subunits, namely Rad21/Mcd1/Scc1, Smc1, Smc3, and one of …

Background TP53, the most frequently mutated gene in human cancers, orchestrates a
complex transcriptional program crucial for cancer prevention. While certain TP53 …

Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) is a human gammaherpesvirus
recognized as the principal causative agent of KS and primary effusion lymphoma (PEL) …

Ubiquitin-dependent unfolding of the CMG helicase by VCP/p97 is required to terminate
DNA replication. Other replisome components are not processed in the same fashion …