Ferroptosis and its potential role in the physiopathology of Parkinson's Disease

L Mahoney-Sánchez, H Bouchaoui, S Ayton… - Progress in …, 2021 - Elsevier
Parkinson's Disease (PD) is a common and progressive neurodegenerative disorder
characterised by motor impairments as well as non-motor symptoms. While dopamine …

Neuroprotective activities of curcumin in Parkinson's disease: a review of the literature

EE Nebrisi - International journal of molecular sciences, 2021 - mdpi.com
Parkinson's disease (PD) is a slowly progressive multisystem disorder affecting
dopaminergic neurons of the substantia nigra pars compacta (SNpc), which is characterized …

Iron deficiency in heart failure: mechanisms and pathophysiology

RIS Alnuwaysir, MF Hoes, DJ van Veldhuisen… - Journal of clinical …, 2021 - mdpi.com
Iron is an essential micronutrient for a myriad of physiological processes in the body beyond
erythropoiesis. Iron deficiency (ID) is a common comorbidity in patients with heart failure …

Ferroptosis in Parkinson's disease: Molecular mechanisms and therapeutic potential

X Ding, L Gao, Z Han, S Eleuteri, W Shi, Y Shen… - Ageing research …, 2023 - Elsevier
Parkinson's Disease (PD) is characterized by the progressive loss of dopaminergic neurons
in the substantia nigra (SN), leading to motor and non-motor symptoms. While the exact …

Nutrition and cognitive health: A life course approach

S Puri, M Shaheen, B Grover - Frontiers in public health, 2023 - frontiersin.org
Multiple factors affect cognitive health, such as age-related changes in the brain, injuries,
mood disorders, substance abuse, and diseases. While some cannot be changed, evidence …

ACSL4 and the lipoxygenases 15/15B are pivotal for ferroptosis induced by iron and PUFA dyshomeostasis in dopaminergic neurons

H Bouchaoui, L Mahoney-Sanchez, G Garçon… - Free Radical Biology …, 2023 - Elsevier
Ferroptosis, an iron-dependent regulated cell death triggered by high lipid peroxide levels,
has been implicated in several neurodegenerative diseases, including Parkinson's disease …

Therapeutic insights on ferroptosis in Parkinson's disease

K Thapa, H Khan, N Kanojia, TG Singh, A Kaur… - European journal of …, 2022 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disorder that alters either motor or non-
motor activities. Dopamine-based medications can help alleviate symptoms at an early …

Whole-exome sequencing identifies protein-coding variants associated with brain iron in 29,828 individuals

W Gong, Y Fu, BS Wu, J Du, L Yang, YR Zhang… - Nature …, 2024 - nature.com
Iron plays a fundamental role in multiple brain disorders. However, the genetic
underpinnings of brain iron and its implications for these disorders are still lacking. Here, we …

Glymphatic function plays a protective role in ageing-related cognitive decline

J Wang, Y Zhou, K Zhang, W Ran, X Zhu… - Age and …, 2023 - academic.oup.com
Objective The glymphatic pathway, characterised as a cerebral drainage system, influences
cognitive function in neurodegenerative diseases; however, evidence is limited in a normal …

Iron and ferroptosis more than a suspect: beyond the most common mechanisms of neurodegeneration for new therapeutic approaches to cognitive decline and …

M Cerasuolo, I Di Meo, MC Auriemma, F Trojsi… - International Journal of …, 2023 - mdpi.com
Neurodegeneration is a multifactorial process that involves multiple mechanisms. Examples
of neurodegenerative diseases are Parkinson's disease, multiple sclerosis, Alzheimer's …