The epithelial to mesenchymal transition (EMT) converts epithelial cells into migratory and
invasive cells and is a fundamental event in morphogenesis. Although its relevance in the …

Both tumor hypoxia and dysregulated metabolism are classical features of cancer. Recent
analyses have revealed complex interconnections between oncogenic activation, hypoxia …

Plasticity of the cell state has been proposed to drive resistance to multiple classes of cancer
therapies, thereby limiting their effectiveness,,,. A high-mesenchymal cell state observed in …

Clear cell renal cell carcinoma (ccRCC) is histologically defined by its lipid and glycogen-
rich cytoplasmic deposits. Alterations in the VHL tumor suppressor stabilizing the hypoxia …

Background With the advent of second-generation sequencing, the expression of gene
transcripts can be digitally measured with high accuracy. The purpose of this study was to …

Kidney cancer [or renal cell carcinoma (RCC)] is known as “the internist's tumor” because it
has protean systemic manifestations, suggesting that it utilizes complex, nonphysiologic …

Cancer cells are characterized by high metabolic demand. The substrates in demand
include oxygen, glucose, glutamine and lipids. Oxygen serves as a key substrate in cellular …

Clear cell renal cell carcinoma (ccRCC) is characterized by accumulation of neutral lipids
and adipogenic transdifferentiation. We assessed adipokine expression in ccRCC and …

Purpose: We set out to identify Stearoyl-CoA desaturase 1 (SCD1) as a novel molecular
target in clear cell renal cell carcinoma (ccRCC) and examine its role in tumor cell growth …

Background: Clear cell renal cell carcinoma (ccRCC) is characterized by glycogen-laden,
unexplained male predominance, and frequent mutations in the Von Hippel-Lindau (VHL) …