The peroxisome proliferator-activated receptors (PPAR-α, PPAR-β/δ, and PPAR-γ) are
members of the nuclear receptor super-family, acting as ligand-inducible transcription …

The effects of brain AngII (angiotensin II) depend on AT1 receptor (AngII type 1 receptor)
stimulation and include regulation of cerebrovascular flow, autonomic and hormonal …

Direct functionalization of azobenzenes provides an approach to obtaining valuable
molecules in synthetic chemistry. However, an efficient method for the cleavage of the N═ N …

A metal-free cross-dehydrogenative coupling method for the synthesis of N-substituted
azoles has been developed. The TBAI/TBHP system catalyzed the coupling of azoles with …

Heterocyclic compounds play a major role in drug discovery processes as these are the
common structural motif for 80% of the marketed drugs by US retail sales in 2014 …

Mining of an in-house collection of angiotensin II type 1 receptor antagonists to identify
compounds with activity at the peroxisome proliferator-activated receptor-γ (PPARγ) …

A series of 2-arylbenzimidazole derivatives (3a–3p and 4a–4i) were synthesized and
evaluated as potential antioxidant and antimicrobial agents. Their antioxidant properties …

Abstract Twelve new 2-quinolizinylbenzimidazole and 2-naphthalylbenzimidazole
derivatives with various 5-and 6-positioned substituents (aza, H, CH 3, Cl, NO 2, NH 2, OCH …

The renin angiotensin system (RAS) plays an important role in regulation of blood pressure
and fluidelectrolyte homeostasis. The renin-angiotensin system consists of a cascade of …

The recent research area endeavors to discover ultimate multi-target ligands, an
increasingly feasible and attractive alternative to existing mono-targeted drugs for treatment …