The sequence of the human genome
A 2.91-billion base pair (bp) consensus sequence of the euchromatic portion of the human
genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion …
genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion …
Coincidence, coevolution, or causation? DNA content, cell size, and the C-value enigma
TR Gregory - Biological reviews, 2001 - cambridge.org
Variation in DNA content has been largely ignored as a factor in evolution, particularly
following the advent of sequence-based approaches to genomic analysis. The significant …
following the advent of sequence-based approaches to genomic analysis. The significant …
Initial sequencing and analysis of the human genome
US DOE Joint Genome Institute: Hawkins Trevor 4 … - Nature, 2001 - nature.com
The human genome holds an extraordinary trove of information about human development,
physiology, medicine and evolution. Here we report the results of an international …
physiology, medicine and evolution. Here we report the results of an international …
Whole-Genome Shotgun Assembly and Analysis of the Genome of Fugu rubripes
The compact genome of Fugu rubripes has been sequenced to over 95% coverage, and
more than 80% of the assembly is in multigene-sized scaffolds. In this 365-megabase …
more than 80% of the assembly is in multigene-sized scaffolds. In this 365-megabase …
Functional and Evolutionary Insights from the Genomes of Three Parasitoid Nasonia Species
We report here genome sequences and comparative analyses of three closely related
parasitoid wasps: Nasonia vitripennis, N. giraulti, and N. longicornis. Parasitoids are …
parasitoid wasps: Nasonia vitripennis, N. giraulti, and N. longicornis. Parasitoids are …
Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor
Although changes in nucleotide sequence affecting the composition and the structure of
proteins are well known, functional changes resulting from nucleotide substitutions cannot …
proteins are well known, functional changes resulting from nucleotide substitutions cannot …
An RNA gene expressed during cortical development evolved rapidly in humans
The developmental and evolutionary mechanisms behind the emergence of human-specific
brain features remain largely unknown. However, the recent ability to compare our genome …
brain features remain largely unknown. However, the recent ability to compare our genome …
Variation in the mutation rate across mammalian genomes
It has been known for many years that the mutation rate varies across the genome. However,
only with the advent of large genomic data sets is the full extent of this variation becoming …
only with the advent of large genomic data sets is the full extent of this variation becoming …
Global reorganization of replication domains during embryonic stem cell differentiation
DNA replication in mammals is regulated via the coordinate firing of clusters of replicons that
duplicate megabase-sized chromosome segments at specific times during S-phase …
duplicate megabase-sized chromosome segments at specific times during S-phase …
Evolution of synonymous codon usage in metazoans
L Duret - Current opinion in genetics & development, 2002 - Elsevier
The vast amount of data generated by genome projects and the recent development of
population genetics models make comparative sequence analyses a very powerful …
population genetics models make comparative sequence analyses a very powerful …