In order to update recommendations on treatment, supportive care, education and follow-up
of patients with invasive cutaneous squamous cell carcinoma (cSCC), a multidisciplinary …

Hematological cancers such as leukemia, lymphoma, and multiple myeloma have
traditionally been treated with chemo and radiotherapy approaches. Introduction of …

Immunomodulatory drugs and monoclonal antibody-based immunotherapies have
significantly improved the prognosis of the patients with multiple myeloma (MM) in the recent …

Purpose: T-cell immunoreceptor with Ig and ITIM domain (TIGIT) blockade could represent
an alternative therapeutic option to release the immune response in patients with multiple …

Normal human cells can either synthesize cholesterol or take it up from lipoproteins to meet
their metabolic requirements. In some malignant cells, de novo cholesterol synthesis genes …

Background. Inducible nitric oxide synthase (iNOS) is confirmed to regulate the production of
nitric oxide (NO) when cells are exposed to external stimulus. Recent publications revealed …

Background: Inhibitors of programmed cell death protein 1 (PD-1) and programmed cell
death ligand 1 (PD-L1) have been used in the treatment of relapsed and refractory …

Immune checkpoints and agonists modulate ongoing, antigen-specific immune responses.
Therapeutic blockade of CTLA-4, PD-1, and PD-L1 has proven to be an effective treatment …

Antibody drug conjugates represent an important class of anti-cancer drugs in both solid
tumors and hematologic cancers. Here, we report preclinical data on the anti-tumor activity …

Extranodal NK/T-cell lymphoma, nasal type (ENKL), is a rare lymphoma subtype of
peripheral T/NK-cell lymphoma that is very common in East Asia and Latin America. Two …