Candidate biomarkers in psychiatric disorders: state of the field
The field of psychiatry is hampered by a lack of robust, reliable and valid biomarkers that can
aid in objectively diagnosing patients and providing individualized treatment …
aid in objectively diagnosing patients and providing individualized treatment …
[HTML][HTML] Alcohol use disorder and depressive disorders
Alcohol use disorder (AUD) and depressive disorders are among the most prevalent
psychiatric disorders and co-occur more often than expected by chance. The aim of this …
psychiatric disorders and co-occur more often than expected by chance. The aim of this …
Harmonization of cortical thickness measurements across scanners and sites
With the proliferation of multi-site neuroimaging studies, there is a greater need for handling
non-biological variance introduced by differences in MRI scanners and acquisition …
non-biological variance introduced by differences in MRI scanners and acquisition …
Statistical harmonization corrects site effects in functional connectivity measurements from multi‐site fMRI data
Acquiring resting‐state functional magnetic resonance imaging (fMRI) datasets at multiple
MRI scanners and clinical sites can improve statistical power and generalizability of results …
MRI scanners and clinical sites can improve statistical power and generalizability of results …
The future of rodent models in depression research
Currently, over 300 million people worldwide have depression, and the socioeconomic
burden of this debilitating disorder is anticipated to increase markedly over the coming …
burden of this debilitating disorder is anticipated to increase markedly over the coming …
Cortico-striatal-thalamic loop circuits of the salience network: a central pathway in psychiatric disease and treatment
The salience network (SN) plays a central role in cognitive control by integrating sensory
input to guide attention, attend to motivationally salient stimuli and recruit appropriate …
input to guide attention, attend to motivationally salient stimuli and recruit appropriate …
A randomized proof-of-mechanism trial applying the 'fast-fail'approach to evaluating κ-opioid antagonism as a treatment for anhedonia
Abstract The National Institute of Mental Health (NIMH)'fast-fail'approach seeks to improve
too-often-misleading early-phase drug development methods by incorporating biomarker …
too-often-misleading early-phase drug development methods by incorporating biomarker …
Computational psychiatry needs time and context
Why has computational psychiatry yet to influence routine clinical practice? One reason may
be that it has neglected context and temporal dynamics in the models of certain mental …
be that it has neglected context and temporal dynamics in the models of certain mental …
Cortico-striatal-thalamic loop circuits of the orbitofrontal cortex: promising therapeutic targets in psychiatric illness
Corticostriatal circuits through the orbitofrontal cortex (OFC) play key roles in complex
human behaviors such as evaluation, affect regulation and reward-based decision-making …
human behaviors such as evaluation, affect regulation and reward-based decision-making …
Measuring depression over time... Or not? Lack of unidimensionality and longitudinal measurement invariance in four common rating scales of depression.
In depression research, symptoms are routinely assessed via rating scales and added to
construct sum-scores. These scores are used as a proxy for depression severity in cross …
construct sum-scores. These scores are used as a proxy for depression severity in cross …