Mass transfer kinetics, band broadening and column efficiency

F Gritti, G Guiochon - Journal of Chromatography A, 2012 - Elsevier
Important progress was recently made in our understanding of the physico-chemical aspects
of mass transfer kinetics in chromatographic columns, in methods used for accurate …

Size-exclusion chromatography—a review of calibration methodologies

LK Kostanski, DM Keller, AE Hamielec - Journal of biochemical and …, 2004 - Elsevier
Recent developments are reviewed in size exclusion chromatographic calibration
methodologies, including direct calibration by using narrow and broad polymer standards …

Morphology-transport relationships in liquid chromatography: Application to method development in size exclusion chromatography

F Gritti, J Hochstrasser, A Svidrytski, D Hlushkou… - … of Chromatography A, 2020 - Elsevier
We present relationships between the multiscale structure and the separation properties of
size exclusion chromatography (SEC) columns. Physical bed reconstructions of wall and …

Molecular dynamic theories in chromatography

A Felinger - Journal of Chromatography A, 2008 - Elsevier
The molecular dynamic model of chromatography is a microscopic model that consists of
two fundamental processes:(i) the random migration of the molecules in the mobile phase …

Resolution limits of size exclusion chromatography columns identified from flow reversal and overcome by recycling liquid chromatography to improve the …

F Gritti - Journal of Chromatography A, 2023 - Elsevier
The flow reversal (FR) technique consists of reversing the flow direction along a
chromatographic column. It is used to reveal the origin (such as poor column packing, active …

Absorption and escape kinetics of spherical biomolecules from fully porous particles utilized in size exclusion chromatography

F Gritti - Journal of Chromatography A, 2023 - Elsevier
The increasing demand for the characterization of large biomolecules such as monoclonal
antibodies, double-stranded deoxyribonucleic acid (dsDNA), and virus-like particles (VLPs) …

Equivalence of the microscopic and macroscopic models of chromatography: stochastic–dispersive versus lumped kinetic model

A Felinger, A Cavazzini, F Dondi - Journal of Chromatography A, 2004 - Elsevier
The microscopic model of chromatography is a stochastic model that consists of two
fundamental processes:(i) the random migration of the molecules in the mobile phase, and …

Method transfer from high-pressure liquid chromatography to ultra-high-pressure liquid chromatography. II. Temperature and pressure effects

D Åsberg, J Samuelsson, M Leśko, A Cavazzini… - … of Chromatography A, 2015 - Elsevier
The importance of the generated temperature and pressure gradients in ultra-high-pressure
liquid chromatography (UHPLC) are investigated and compared to high-pressure liquid …

Stochastic theory of size exclusion chromatography: Peak shape analysis on single columns

A Felinger, L Pasti, F Dondi, M van Hulst… - Analytical …, 2005 - ACS Publications
The stochastic theory of size exclusion chromatography (SEC) was applied to analyze the
peak shape of chromatograms obtained with a wide range of polystyrene standards on …

Determination of the pore size distribution of high-performance liquid chromatography stationary phases via inverse size exclusion chromatography

I Bacskay, A Sepsey, A Felinger - Journal of Chromatography A, 2014 - Elsevier
Stationary phases in liquid chromatography exhibit quite different pore structures. Whereas
most of the fully porous packing materials possess a narrow pore size distribution, core …