Recent development of gold (I) and gold (III) complexes as therapeutic agents for cancer diseases
Y Lu, X Ma, X Chang, Z Liang, L Lv, M Shan… - Chemical Society …, 2022 - pubs.rsc.org
Metal complexes have demonstrated significant antitumor activities and platinum complexes
are well established in the clinical application of cancer chemotherapy. However, the …
are well established in the clinical application of cancer chemotherapy. However, the …
Antioxidant enzymes and their potential use in breast cancer treatment
MM Vilchis-Landeros, H Vázquez-Meza… - International Journal of …, 2024 - mdpi.com
According to the World Health Organization (WHO), breast cancer (BC) is the deadliest and
the most common type of cancer worldwide in women. Several factors associated with BC …
the most common type of cancer worldwide in women. Several factors associated with BC …
1, 2, 4-Triazole derivatives as novel and potent antifungal agents: Design, synthesis and biological evaluation
Fungal infections are still threatening human health due to resistance to existing drugs,
therefore, the design and development of novel antifungal agents is to be necessary and …
therefore, the design and development of novel antifungal agents is to be necessary and …
Thioredoxin reductase inhibitors: updated patent review (2017-present)
ABSTRACT Introduction: Thioredoxin reductase (TrxR) is a selenocysteine-containing
enzyme which is responsible–as a part of the thioredoxin system–for maintaining redox …
enzyme which is responsible–as a part of the thioredoxin system–for maintaining redox …
Design, synthesis, molecular simulation, and biological activities of novel quinazolinone-pyrimidine hybrid derivatives as dipeptidyl peptidase-4 inhibitors and …
Two novel series of quinazolinone–pyrimidine (series a: 9a–9i) and benzyl-pyrimidine
hybrids (series b: 12a–12c) were designed, synthesized and characterized by spectroscopic …
hybrids (series b: 12a–12c) were designed, synthesized and characterized by spectroscopic …
Trends in small organic fluorescent scaffolds for detection of oxidoreductase
Oxidoreductases are diverse class of enzymes engaged in modulating the redox
homeostasis and cellular signaling cascades. Abnormal expression of oxidoreductases …
homeostasis and cellular signaling cascades. Abnormal expression of oxidoreductases …
Novel N‐substituted isatin‐ampyrone Schiff bases as a new class of antiproliferative agents: Design, synthesis, molecular modeling and in vitro cytotoxic activity
Thirteen novel isatin‐ampyrone Schiff bases derivatives were synthesized in only two steps
of 70%–90% overall yields. In vitro cytotoxic activity of these new Schiff bases against three …
of 70%–90% overall yields. In vitro cytotoxic activity of these new Schiff bases against three …
Half-Sandwich Cyclometalated RhIII Complexes Bearing Thiolate Ligands: Biomolecular Interactions and In Vitro and In Vivo Evaluations
A class of cyclometalated RhIII complexes [Cp* Rh (ppy)(SR)] bearing thiolate ligands, Cp*=
pentamethylcyclopentadienyl, ppy= 2-phenylpyridinate, and R= pyridyl (Spy, 2), pyrimidyl …
pentamethylcyclopentadienyl, ppy= 2-phenylpyridinate, and R= pyridyl (Spy, 2), pyrimidyl …
Aryloxy Alkyl theophylline derivatives as antifungal agents: design, synthesis, biological evaluation and computational studies
Infectious diseases are still one of the leading causes of death and disability in human
society. Synthetic antimicrobial agents have recently emerged as promising candidates …
society. Synthetic antimicrobial agents have recently emerged as promising candidates …
A new gold (I) phosphine complex induces apoptosis in prostate cancer cells by increasing reactive oxygen species
Y Wang, H Yuan, R Fang, J Lu, J Duo, G Li… - Molecular and Cellular …, 2024 - Springer
Thioredoxin reductase (TrxR) is a pivotal regulator of redox homeostasis. It is frequently
overexpressed in various cancer cells, including prostate cancer, making it a promising …
overexpressed in various cancer cells, including prostate cancer, making it a promising …