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Experimental murine models for colorectal cancer research
Simple Summary In its early stages, colorectal cancer (CRC) is a localized tumor, but when it
metastasizes, it has dramatic consequences. Murine models in CRC research are important …
metastasizes, it has dramatic consequences. Murine models in CRC research are important …
TEAD Inhibition Overcomes YAP1/TAZ-Driven Primary and Acquired Resistance to KRASG12C Inhibitors
AC Edwards, CA Stalnecker, A Jean Morales… - Cancer …, 2023 - aacrjournals.org
Primary/intrinsic and treatment-induced acquired resistance limit the initial response rate to
and long-term efficacy of direct inhibitors of the KRASG12C mutant in cancer. To identify …
and long-term efficacy of direct inhibitors of the KRASG12C mutant in cancer. To identify …
Sulfoconjugation of protein peptides and glycoproteins in physiology and diseases
P Xu, X Cai, X Guan, W ** proteome architecture from protein complexes to subcellular localizations
Proteins are responsible for most intracellular functions, which they perform as part of higher-
order molecular complexes, located within defined subcellular niches. Localization is both …
order molecular complexes, located within defined subcellular niches. Localization is both …
ECT2 promotes malignant phenotypes through the activation of the AKT/mTOR pathway and cisplatin resistance in cervical cancer
X Liu, J Zhang, S Ju, L Liu, Y Sun, L Guo, Q Zhen… - Cancer gene …, 2023 - nature.com
Epithelial cell transforming sequence 2 (ECT2) is expressed at high levels in various
malignancies and contributes to malignant phenotypes in cancers. However, ECT2 is still …
malignancies and contributes to malignant phenotypes in cancers. However, ECT2 is still …
[HTML][HTML] Sulfation of chondroitin and bile acids converges to antagonize Wnt/β-catenin signaling and inhibit APC deficiency-induced gut tumorigenesis
Sulfation is a crucial and prevalent conjugation reaction involved in cellular processes and
mammalian physiology. 3′-Phosphoadenosine 5′-phosphosulfate (PAPS) synthase 2 …
mammalian physiology. 3′-Phosphoadenosine 5′-phosphosulfate (PAPS) synthase 2 …