Mesenchymal stem cell-based therapy for cardiovascular disease: progress and challenges

L Bagno, KE Hatzistergos, W Balkan, JM Hare - Molecular Therapy, 2018 - cell.com
Administration of mesenchymal stem cells (MSCs) to diseased hearts improves cardiac
function and reduces scar. These effects occur via stimulation of endogenous repair …

[HTML][HTML] Mesenchymal stem cell secretome as an emerging cell-free alternative for improving wound repair

P Ahangar, SJ Mills, AJ Cowin - International journal of molecular …, 2020 - mdpi.com
The use of mesenchymal stem cells (MSC) for the treatment of cutaneous wounds is
currently of enormous interest. However, the broad translation of cell therapies into clinical …

3D printed complex tissue construct using stem cell-laden decellularized extracellular matrix bioinks for cardiac repair

J Jang, HJ Park, SW Kim, H Kim, JY Park, SJ Na… - Biomaterials, 2017 - Elsevier
Stem cell therapy is a promising therapeutic method for the treatment of ischemic heart
diseases; however, some challenges prohibit the efficacy after cell delivery due to hostile …

Physiological implications of myocardial scar structure

WJ Richardson, SA Clarke, TA Quinn… - Comprehensive …, 2015 - pmc.ncbi.nlm.nih.gov
Once myocardium dies during a heart attack, it is replaced by scar tissue over the course of
several weeks. The size, location, composition, structure and mechanical properties of the …

Proangiogenic features of mesenchymal stem cells and their therapeutic applications

H Tao, Z Han, ZC Han, Z Li - Stem cells international, 2016 - Wiley Online Library
Mesenchymal stem cells (MSCs) have shown their therapeutic potency for treatment of
cardiovascular diseases owing to their low immunogenicity, ease of isolation and …

A viscoelastic adhesive epicardial patch for treating myocardial infarction

X Lin, Y Liu, A Bai, H Cai, Y Bai, W Jiang… - Nature biomedical …, 2019 - nature.com
Acellular epicardial patches that treat myocardial infarction by increasing the mechanical
integrity of damaged left ventricular tissues exhibit widely scattered therapeutic efficacy …

Cardiac fibrosis: potential therapeutic targets

S Park, NB Nguyen, A Pezhouman, R Ardehali - Translational Research, 2019 - Elsevier
Cardiovascular disease is a leading cause of mortality in the world and is exacerbated by
the presence of cardiac fibrosis, defined by the accumulation of noncontractile extracellular …

Enhancement of mesenchymal stem cell angiogenic capacity and stemness by a biomimetic hydrogel scaffold

KC Rustad, VW Wong, M Sorkin, JP Glotzbach… - Biomaterials, 2012 - Elsevier
In this study, we examined the capacity of a biomimetic pullulan–collagen hydrogel to create
a functional biomaterial-based stem cell niche for the delivery of mesenchymal stem cells …

Physiological function and transplantation of scaffold-free and vascularized human cardiac muscle tissue

KR Stevens, KL Kreutziger, SK Dupras… - Proceedings of the …, 2009 - pnas.org
Success of human myocardial tissue engineering for cardiac repair has been limited by
adverse effects of scaffold materials, necrosis at the tissue core, and poor survival after …

[HTML][HTML] Drug and cell delivery for cardiac regeneration

CL Hastings, ET Roche, E Ruiz-Hernandez… - Advanced drug delivery …, 2015 - Elsevier
The spectrum of ischaemic cardiomyopathy, encompassing acute myocardial infarction to
congestive heart failure is a significant clinical issue in the modern era. This group of …