Understanding and controlling the interaction of nanomaterials with proteins in a physiological environment

CD Walkey, WCW Chan - Chemical Society Reviews, 2012 - pubs.rsc.org
Nanomaterials hold promise as multifunctional diagnostic and therapeutic agents. However,
the effective application of nanomaterials is hampered by limited understanding and control …

Protein− nanoparticle interactions: opportunities and challenges

M Mahmoudi, I Lynch, MR Ejtehadi… - Chemical …, 2011 - ACS Publications
In recent years, the fabrication of nanomaterials and exploration of their properties have
attracted the attention of all branches of science, such as physics, chemistry, biology, and …

Understanding the nanoparticle–protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles

T Cedervall, I Lynch, S Lindman… - Proceedings of the …, 2007 - National Acad Sciences
Due to their small size, nanoparticles have distinct properties compared with the bulk form of
the same materials. These properties are rapidly revolutionizing many areas of medicine …

Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy

P Aggarwal, JB Hall, CB McLeland… - Advanced drug delivery …, 2009 - Elsevier
Proteins bind the surfaces of nanoparticles, and biological materials in general, immediately
upon introduction of the materials into a physiological environment. The further biological …

Polysaccharides-based nanoparticles as drug delivery systems

Z Liu, Y Jiao, Y Wang, C Zhou, Z Zhang - Advanced drug delivery reviews, 2008 - Elsevier
Natural polysaccharides, due to their outstanding merits, have received more and more
attention in the field of drug delivery systems. In particular, polysaccharides seem to be the …

The nanoparticle biomolecule corona: lessons learned–challenge accepted?

D Docter, D Westmeier, M Markiewicz… - Chemical Society …, 2015 - pubs.rsc.org
Besides the wide use of engineered nanomaterials (NMs) in technical products, their
applications are not only increasing in biotechnology and biomedicine, but also in the …

Methods for the preparation and manufacture of polymeric nanoparticles

C Vauthier, K Bouchemal - Pharmaceutical research, 2009 - Springer
This review summarizes the different methods of preparation of polymer nanoparticles
including nanospheres and nanocapsules. The first part summarizes the basic principle of …

The evolution of the protein corona around nanoparticles: a test study

M Lundqvist, J Stigler, T Cedervall, T Berggard… - ACS …, 2011 - ACS Publications
The importance of the protein corona formed around nanoparticles upon entering a
biological fluid has recently been highlighted. This corona is, when sufficiently long-lived …

Chemical basis of interactions between engineered nanoparticles and biological systems

Q Mu, G Jiang, L Chen, H Zhou, D Fourches… - Chemical …, 2014 - ACS Publications
As defined by the European Commission, a nanomaterial is a natural, an incidental, or a
manufactured material containing particles in an unbound state or as an aggregate or …

Nucleation of protein fibrillation by nanoparticles

S Linse, C Cabaleiro-Lago, WF Xue… - Proceedings of the …, 2007 - National Acad Sciences
Nanoparticles present enormous surface areas and are found to enhance the rate of protein
fibrillation by decreasing the lag time for nucleation. Protein fibrillation is involved in many …