Escherichia coli is considered to be the best-known microorganism given the large number
of published studies detailing its genes, its genome and the biochemical functions of its …

Metabolic engineering allows development of microbial strains efficiently producing
chemicals and materials, but it requires much time, effort, and cost to make the strains …

Genome-scale metabolic models (GEMs) are valuable tools to study metabolism and
provide a scaffold for the integrative analysis of omics data. Researchers have developed …

Knowing the catalytic turnover numbers of enzymes is essential for understanding the
growth rate, proteome composition, and physiology of organisms, but experimental data on …

Mycobacterium tuberculosis is a serious human pathogen threat exhibiting complex
evolution of antimicrobial resistance (AMR). Accordingly, the many publicly available …

The yeast Saccharomyces cerevisiae is widely used as a cell factory and as an important
eukaryal model organism for studying cellular physiology related to human health and …

The influence of metabolism on signaling, epigenetic markers, and transcription is highly
complex yet important for understanding cancer physiology. Despite the development of …

Antimicrobial resistance (AMR) in bacteria is a global health crisis due to the rapid
emergence of multidrug-resistant bacteria and the lengthy development of new …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a rapidly growing
infectious disease, widely spread with high mortality rates. Since the release of the SARS …

Genome-scale models of metabolism (GEMs) are key computational tools for the systems-
level study of metabolic networks. Here, we describe the" GEM life cycle," which we …