The role of fluorine in drug design and development is expanding rapidly as we learn more
about the unique properties associated with this unusual element and how to deploy it with …

The high utility of halogenated organic compounds has prompted the development of a vast
number of transformations which install the carbon–halogen motif. Traditional routes to …

Taking into account the vast arrays of fluorinated motifs known, 11 this review will be limited
to the monofluorination of organic compounds, ie, synthetic methods allowing the …

Transition metal-catalysed cross-coupling is one of the most powerful synthetic methods and
has led to vast improvements in the synthesis of pharmaceuticals, agrochemicals and …

Over the past three decades, Pd-catalyzed cross-coupling reactions have become a
mainstay of organic synthesis. In particular, catalysts derived from biaryl monophosphines …

Aryl fluorides are important structural motifs in many pharmaceuticals. Although the Balz–
Schiemann reaction provides an entry to aryl fluorides from aryldiazonium …

In recent years, there has been a dramatic increase in available methods for the installation
of fluorine and fluorine-containing functional groups in organic molecules, 1− 4 and the …

Fluorinated quinolines and pyridines are prevalent pharmacophores, yet their synthesis is
often challenging. Herein, we demonstrate that dibromofluoromethane as …

Charming fluorine: This Essay examines the recent surge in late-stage fluorination reactions
and outlines challenges that need to be overcome to increase the impact of modern …

The challenges of the modern society and the growing demand of high-technology sectors
of industrial production bring about a new phase in the development of organic synthesis. A …