Mutations in the leucine-rich-repeat kinase 2 (LRRK2) gene are associated with familial and
sporadic cases of Parkinson's disease but are also found in immune-related disorders such …

Leprosy, a disease caused by the intracellular parasite Mycobacterium leprae or
Mycobacterium lepromatosis, has affected humans for more than 4,000 years and is a …

Mycobacterium leprae, the causative agent of leprosy, is still actively transmitted in endemic
areas reflected by the fairly stable number of new cases detected each year. Recognizing …

Background Depending on the epidemiological setting, a variable proportion of leprosy
patients will suffer from excessive pro-inflammatory responses, termed type-1 reactions …

Erythema nodosum leprosum (ENL) is a manifestation of type II lepra reaction, seen in
lepromatous or borderline lepromatous leprosy. Although it is a common reaction …

Age is the greatest risk factor for many neurodegenerative diseases, yet immune system
aging, a contributor to neurodegeneration, is understudied. Genetic variation in the LRRK2 …

Leprosy is still a considerable health threat in pockets of several low and middle income
countries worldwide where intense transmission is witnessed, and often results in …

Type-1 reactions (T1R) are pathological inflammatory episodes and main contributors to
nerve damage in leprosy. Here, we evaluate the genewise enrichment of rare protein …

Abstract Erythema Nodosum Leprosum (ENL) occurs due to the immunological complication
of multibacillary leprosy and is characterized by painful nodules and systemic …

The pathways that trigger exacerbated immune reactions in leprosy could be determined by
genetic variations. Here, in a prospective approach, both genetic and non-genetic variables …