The current understanding of lactate extends from its origins as a byproduct of glycolysis to
its role in tumor metabolism, as identified by studies on the Warburg effect. The lactate …

Cancer cells undergo metabolic alterations to meet the immense demand for energy,
building blocks, and redox potential. Tumors show glucose-avid and lactate-secreting …

High expression of PD-L1 in tumor cells contributes to tumor immune evasion. However,
whether PD-L1 expression in tumor cells is regulated by the availability of nutrients is …

Activation of receptor protein kinases is prevalent in various cancers with unknown impact
on ferroptosis. Here we demonstrated that AKT activated by insulin-like growth factor 1 …

It is generally thought that under basal conditions, neurons produce ATP mainly through
mitochondrial oxidative phosphorylation (OXPHOS), and glycolytic activity only …

Metabolic enzymes have an indispensable role in metabolic reprogramming, and their
aberrant expression or activity has been associated with chemosensitivity. Hence, targeting …

Dysregulation in lipid metabolism is among the most prominent metabolic alterations in
cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological …

Pancreatic cancer is an increasingly common cause of cancer mortality with a tight
correspondence between disease mortality and incidence. Furthermore, it is usually …

Cancer cells characterized by uncontrolled growth and proliferation require altered
metabolic processes to maintain this characteristic. Metabolic reprogramming is a process …

Aerobic glycolysis is an emerging hallmark of many human cancers, as cancer cells are
defined as a “metabolically abnormal system”. Carbohydrates are metabolically …