Genodermatoses represent a large group of inherited skin disorders encompassing
clinically-heterogeneous conditions that manifest in the skin and other organs. Depending …

There are many skin disorders that affect human beings and symptoms of many skin
diseases are common. Therefore, understanding the real differences between them is …

The deletion of exon 18 from Col17a1 in transgenic ΔNC14A mice results in the absence of
the NC14A domain. NC14A corresponds to the human NC16A domain, the …

Epidermolysis bullosa (EB) is a group of rare genetic skin fragility disorders, which are
hereditary. These disorders are associated with mutations in at least 16 genes that encode …

Collagen VII is the main constituent of the anchoring fibrils, important adhesive structures
that attach the epidermis to the dermal extracellular matrix. Two disorders are caused by …

An extracellular matrix (ECM) is essential for multicellular life. Apart from being a scaffold, it
is an actively signalling unit, orchestrating homo‐and heterocellular communication to …

Epidermolysis bullosa simplex is a disease that belongs to a group of genodermatoses
characterised by the formation of superficial bullous lesions caused by minor mechanical …

B‐cell tolerance to self‐antigen is an active process that requires the temporal and spatial
integration of signals of defined intensity. In common variable immune deficiency disorders …

Kollagen VII ist der Hauptbestandteil der Verankerungsfibrillen, wichtigen adhäsiven
Strukturen, die die Epidermis an der extrazellulären Matrix der Dermis befestigen. Zwei …