Cancer biology involves complex, dynamic interactions between cancer cells and their
tissue microenvironments. Single-cell effects are critical drivers of clinical progression …

Glioblastoma (GBM) is a particularly devastating tumor with a median survival of about 16
months. Recent research has revealed novel insights into the outstanding heterogeneity of …

Glioblastoma multiforme is the most aggressive malignant tumor of the central nervous
system. Due to the absence of effective pharmacological and surgical treatments, the …

Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive type of cancer with
an overall survival rate of less than 7-8%, emphasizing the need for novel effective …

Multiscale systems biology and systems pharmacology are powerful methodologies that are
playing increasingly important roles in understanding the fundamental mechanisms of …

In this chapter we have presented mathematical modeling approaches to biological pattern
formation. While reaction-diffusion models are appropriate to describe the spatio-temporal …

The anti-tumor activity of the immune system is increasingly recognized as critical for the
mounting of a prolonged and effective response to cancer growth and invasion, and for …

Digital twins employ mathematical and computational models to virtually represent a
physical object (eg, planes and human organs), predict the behavior of the object, and …

Glioma is the most aggressive brain tumor of the central nervous system. The ability of
glioma cells to migrate, rapidly diffuse and invade normal adjacent tissue, their sustained …

Glioblastoma (GBM) is a highly invasive brain tumor, whose cells infiltrate surrounding
normal brain tissue beyond the lesion outlines visible in the current medical scans. These …