The technological landscape and applications of single-cell multi-omics
Single-cell multi-omics technologies and methods characterize cell states and activities by
simultaneously integrating various single-modality omics methods that profile the …
simultaneously integrating various single-modality omics methods that profile the …
Characterizing cis-regulatory elements using single-cell epigenomics
Cell type-specific gene expression patterns and dynamics during development or in disease
are controlled by cis-regulatory elements (CREs), such as promoters and enhancers …
are controlled by cis-regulatory elements (CREs), such as promoters and enhancers …
[HTML][HTML] Organization of the human intestine at single-cell resolution
The intestine is a complex organ that promotes digestion, extracts nutrients, participates in
immune surveillance, maintains critical symbiotic relationships with microbiota and affects …
immune surveillance, maintains critical symbiotic relationships with microbiota and affects …
Dictionary learning for integrative, multimodal and scalable single-cell analysis
Map** single-cell sequencing profiles to comprehensive reference datasets provides a
powerful alternative to unsupervised analysis. However, most reference datasets are …
powerful alternative to unsupervised analysis. However, most reference datasets are …
Chemical reprogramming of human somatic cells to pluripotent stem cells
J Guan, G Wang, J Wang, Z Zhang, Y Fu, L Cheng… - Nature, 2022 - nature.com
Cellular reprogramming can manipulate the identity of cells to generate the desired cell
types,–. The use of cell intrinsic components, including oocyte cytoplasm and transcription …
types,–. The use of cell intrinsic components, including oocyte cytoplasm and transcription …
Neutrophils and emergency granulopoiesis drive immune suppression and an extreme response endotype during sepsis
Sepsis arises from diverse and incompletely understood dysregulated host response
processes following infection that leads to life-threatening organ dysfunction. Here we …
processes following infection that leads to life-threatening organ dysfunction. Here we …
Single-cell multi-omics identifies chronic inflammation as a driver of TP53-mutant leukemic evolution
Understanding the genetic and nongenetic determinants of tumor protein 53 (TP53)-
mutation-driven clonal evolution and subsequent transformation is a crucial step toward the …
mutation-driven clonal evolution and subsequent transformation is a crucial step toward the …
Single-cell analyses define a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancer
WR Becker, SA Nevins, DC Chen, R Chiu… - Nature …, 2022 - nature.com
To chart cell composition and cell state changes that occur during the transformation of
healthy colon to precancerous adenomas to colorectal cancer (CRC), we generated single …
healthy colon to precancerous adenomas to colorectal cancer (CRC), we generated single …
Genome-wide enhancer maps link risk variants to disease genes
Genome-wide association studies (GWAS) have identified thousands of noncoding loci that
are associated with human diseases and complex traits, each of which could reveal insights …
are associated with human diseases and complex traits, each of which could reveal insights …
Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells
Recent technological advances have enabled massively parallel chromatin profiling with
scATAC-seq (single-cell assay for transposase accessible chromatin by sequencing). Here …
scATAC-seq (single-cell assay for transposase accessible chromatin by sequencing). Here …