Gastric cancer (GC) ranks fifth in global cancer diagnosis and fourth in cancer-related death.
Despite tremendous progress in diagnosis and therapeutic strategies and significant …

The c-Jun N-terminal kinases (JNKs), with its members JNK1, JNK2, and JNK3, is a
subfamily of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide …

Abstract NMDA (N-methyl-d-aspartate) receptors (NMDARs) play a central role in excitotoxic
neuronal death caused by ischemic stroke, but NMDAR channel blockers have failed to be …

The c-Jun N-terminal kinases (JNKs), as members of the mitogen-activated protein kinase
(MAPK) family, mediate eukaryotic cell responses to a wide range of abiotic and biotic stress …

Stress-signaling pathways are evolutionarily conserved and play an important role in the
maintenance of homeostasis. These pathways are also critical for adaptation to new cellular …

Excitotoxicity, the specific type of neurotoxicity mediated by glutamate, may be the missing
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …

Background The decreased marriage satisfaction has become one of the main reasons for
the rising divorce rate. However, few studies have focused on the relationship between …

JNK is named after c-Jun N-terminal kinase, as it is responsible for phosphorylating c-Jun.
As a member of the mitogen-activated protein kinase (MAPK) family, JNK is also known as …

The mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs by
relaying extracellular signals to intracellular responses. In mammals, there are more than a …

Glaucoma is a group of diseases characterized by progressive optic nerve degeneration that
results in visual field loss and irreversible blindness. A crucial element in the …