Advanced methods for natural products discovery: bioactivity screening, dereplication, metabolomics profiling, genomic sequencing, databases and informatic tools …
Natural Products (NP) are essential for the discovery of novel drugs and products for
numerous biotechnological applications. The NP discovery process is expensive and time …
numerous biotechnological applications. The NP discovery process is expensive and time …
Natural products targeting strategies involving molecular networking: different manners, one goal
Covering: up to 2019 Landmark advances in bioinformatics tools have recently enhanced
the field of natural products research, putting today's natural product chemists in the …
the field of natural products research, putting today's natural product chemists in the …
Reproducible molecular networking of untargeted mass spectrometry data using GNPS
Abstract Global Natural Product Social Molecular Networking (GNPS) is an interactive online
small molecule–focused tandem mass spectrometry (MS2) data curation and analysis …
small molecule–focused tandem mass spectrometry (MS2) data curation and analysis …
[HTML][HTML] MolNetEnhancer: enhanced molecular networks by integrating metabolome mining and annotation tools
Metabolomics has started to embrace computational approaches for chemical interpretation
of large data sets. Yet, metabolite annotation remains a key challenge. Recently, molecular …
of large data sets. Yet, metabolite annotation remains a key challenge. Recently, molecular …
Accelerating metabolite identification in natural product research: toward an ideal combination of liquid chromatography–high-resolution tandem mass spectrometry …
Natural product research aims to characterize specialized metabolites from various living
organisms and assess their biological properties from either a chemical ecology or drug …
organisms and assess their biological properties from either a chemical ecology or drug …
Good practices and recommendations for using and benchmarking computational metabolomics metabolite annotation tools
Background Untargeted metabolomics approaches based on mass spectrometry obtain
comprehensive profiles of complex biological samples. However, on average only 10% of …
comprehensive profiles of complex biological samples. However, on average only 10% of …
Innovative omics-based approaches for prioritisation and targeted isolation of natural products–new strategies for drug discovery
Covering: 2013 to 2019 The exploration of the chemical diversity of extracts from various
biological sources has led to major drug discoveries. Over the past two decades, despite the …
biological sources has led to major drug discoveries. Over the past two decades, despite the …
Concepts and methods to access novel antibiotics from actinomycetes
Actinomycetes have been proven to be an excellent source of secondary metabolites for
more than half a century. Exhibiting various bioactivities, they provide valuable approved …
more than half a century. Exhibiting various bioactivities, they provide valuable approved …
[HTML][HTML] Insight into chemical basis of traditional Chinese medicine based on the state-of-the-art techniques of liquid chromatography− mass spectrometry
Y Yu, C Yao, D Guo - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Traditional Chinese medicine (TCM) has been an indispensable source of drugs for curing
various human diseases. However, the inherent chemical diversity and complexity of TCM …
various human diseases. However, the inherent chemical diversity and complexity of TCM …
Omics and multi-omics approaches to study the biosynthesis of secondary metabolites in microorganisms
Highlights•Microorganisms are a prolific source of highly bioactive compounds.•Omics
approaches to unveil biosynthetic gene clusters encoding new natural product.•Use multi …
approaches to unveil biosynthetic gene clusters encoding new natural product.•Use multi …