Cancer stem cells: Advances in knowledge and implications for cancer therapy

X Chu, W Tian, J Ning, G **ao, Y Zhou… - … and Targeted Therapy, 2024 - nature.com
Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy

M Chehelgerdi, F Behdarvand Dehkordi… - Molecular cancer, 2023 - Springer
The advent of iPSCs has brought about a significant transformation in stem cell research,
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …

Cancer-inducing niche: the force of chronic inflammation

SM Afify, G Hassan, A Seno, M Seno - British journal of cancer, 2022 - nature.com
The growth of cancer tissue is thought to be considered driven by a small subpopulation of
cells, so-called cancer stem cells (CSCs). CSCs are located at the apex of a hierarchy in a …

How can we turn the PI3K/AKT/mTOR pathway down? Insights into inhibition and treatment of cancer

SM Afify, AKK Oo, G Hassan, A Seno… - Expert Review of …, 2021 - Taylor & Francis
ABSTRACT Introduction: The phosphatidylinositol 3-kinase/protein kinase-B/mammalian
target of rapamycin (PI3K/AKT/mTOR) pathway is a fundamental regulator of cell …

Chronic exposure to FGF2 converts iPSCs into cancer stem cells with an enhanced integrin/focal adhesion/PI3K/AKT axis

M Sheta, G Hassan, SM Afify, S Monzur, K Kumon… - Cancer Letters, 2021 - Elsevier
We previously demonstrated the conversion of normal stem cells, including induced
pluripotent stem cells (iPSCs), into cancer stem cells (CSCs) without genetic manipulation …

ERBB signaling pathway in cancer stem cells

G Hassan, M Seno - Cancer Stem Cell Markers and Related Network …, 2023 - Springer
The epidermal growth factor receptor (EGFR) was first tyrosine kinase receptor linked to
human cancers. EGFR or ERBB1 is a member of ERBB subfamily, which consists of four …

Machine learning-based prediction of survival prognosis in cervical cancer

D Ding, T Lang, D Zou, J Tan, J Chen, L Zhou… - BMC …, 2021 - Springer
Background Accurately forecasting the prognosis could improve cervical cancer
management, however, the currently used clinical features are difficult to provide enough …

The efficacy of PI3Kγ and EGFR inhibitors on the suppression of the characteristics of cancer stem cells

Y Xu, SM Afify, J Du, B Liu, G Hassan, Q Wang, H Li… - Scientific reports, 2022 - nature.com
Cancer stem cells (CSCs) are capable of continuous proliferation, self-renewal and are
proposed to play significant roles in oncogenesis, tumor growth, metastasis and cancer …

Combined GSK-3β and MEK inhibitors modulate the stemness and radiotherapy sensitivity of cervical cancer stem cells through the Wnt signaling pathway

C Wang, L Liu, Y Cheng, H Shi - Chemico-Biological Interactions, 2023 - Elsevier
Cancer stem cells (CSCs) are the basis of cancer and lead to the recurrence and metastasis
of cervical cancer. The aim of this study was to investigate the effects of antineoplastic …

iPSC-derived glioblastoma cells have enhanced stemness Wnt/β-catenin activity which is negatively regulated by Wnt antagonist sFRP4

IA Yasmin, A Dharmarajan, S Warrier - Cancers, 2023 - mdpi.com
Simple Summary Cancer is the second most complex disease after cardiovascular disease.
Glioblastoma multiforme (GBM) is a heterogeneous tumor in which the small population of …