In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

Brain tissue has a remarkable ability to accumulate glutamate. This ability is due to
glutamate transporter proteins present in the plasma membranes of both glial cells and …

Glutamate is a fundamental excitatory neurotransmitter in the mammalian central nervous
system (CNS), playing key roles in memory, neuronal development, and synaptic plasticity …

Anxiety and stress disorders are the most commonly occurring of all mental illnesses, and
current treatments are less than satisfactory. So, the discovery of novel approaches to treat …

Metabotropic glutamate (mGlu) receptors, which include mGlu1–8 receptors, are a
heterogeneous family of G-protein-coupled receptors which function to modulate brain …

Glutamate acts on postsynaptic glutamate receptors to mediate excitatory communication
between neurons. The discovery that additional presynaptic glutamate receptors can …

Coherent activations of brain neuron networks underlie many physiological functions
associated with various behavioral states. These synchronous fluctuations in the electrical …

GABAA receptors can mediate both'phasic'synaptic inhibition and a persistent'tonic'form of
signaling. We show that, in the presence of intact GABA uptake, guinea pig hippocampal …

Abstract System xc− represents an intriguing target in attempts to understand the
pathological states of the central nervous system. Also called a cystine-glutamate antiporter …

Accumulating evidence indicates that nitric oxide (NO) inhibits the function of monoamine
transporters. Because the production of NO by neuronal NO synthase (nNOS) is closely …