The ciliopathies are an apparently disparate group of human diseases that all result from
defects in the formation and/or function of cilia. They include disorders such as Meckel …

Aging is a major risk factor for a large number of disorders and functional impairments.
Therapeutic targeting of the aging process may therefore represent an innovative strategy in …

The use of model organisms to provide information on gene function has proved to be a
powerful approach to our understanding of both human disease and fundamental …

The hormone calcitonin (CT) is primarily known for its pharmacologic action as an inhibitor
of bone resorption, yet CT-deficient mice display increased bone formation. These findings …

Translation of the expanded (ggggcc) n repeat in C9orf72 patients with amyotrophic lateral
sclerosis (ALS) and frontotemporal dementia (FTD) causes abundant poly-GA inclusions. To …

All current smooth muscle cell (SMC) Cre mice similarly recombine floxed alleles in vascular
and visceral SMCs. Here we present an Itga8-CreER T2 knock-in mouse and compare its …

Cortical spreading depression (CSD), a wave of depolarization followed by depression of
cortical activity, is a pathophysiological process implicated in migraine with aura and various …

Mitochondrial fusion and fission accompany adaptive responses to stress and altered
metabolic demands. Inner membrane fusion and cristae morphogenesis depends on optic …

Although various mouse inbred strains are widely used to investigate disease mechanisms
and to establish new therapeutic strategies, sex-specific reference intervals for laboratory …

Recently, covalent modifications of RNA, such as methylation, have emerged as key
regulators of all aspects of RNA biology and have been implicated in numerous diseases …