Clonal haematopoiesis and dysregulation of the immune system

R Belizaire, WJ Wong, ML Robinette… - Nature Reviews …, 2023 - nature.com
Age-related diseases are frequently linked to pathological immune dysfunction, including
excessive inflammation, autoreactivity and immunodeficiency. Recent analyses of human …

VEXAS syndrome

PC Grayson, BA Patel, NS Young - Blood, The Journal of the …, 2021 - ashpublications.org
VEXAS syndrome (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) is a
monogenic disease of adulthood caused by somatic mutations in UBA1 in hematopoietic …

Systemic inflammatory and autoimmune manifestations associated with myelodysplastic syndromes and chronic myelomonocytic leukaemia: a French multicentre …

A Mekinian, E Grignano, T Braun, O Decaux… - …, 2016 - academic.oup.com
Objective. We describe myelodysplastic syndrome (MDS)–associated systemic inflammatory
and autoimmune diseases (SIADs), their treatments and outcomes and the impact of SIADs …

Autoimmune manifestations associated with myelodysplastic syndromes

E Grignano, V Jachiet, P Fenaux, L Ades, O Fain… - Annals of …, 2018 - Springer
Autoimmune disorders (ADs) are encountered in 10 to 20% of patients with myelodysplastic
syndromes (MDS). Available data suggest that ADs concern more often younger patients …

Immune dysregulation in myelodysplastic syndrome: clinical features, pathogenesis and therapeutic strategies

C Wang, Y Yang, S Gao, J Chen, J Yu, H Zhang… - Critical reviews in …, 2018 - Elsevier
Myelodysplastic syndrome (MDS) is a heterogeneous hematological malignancy,
characterized by cytopenia and accompanied by a risk of transformation into acute myeloid …

Systemic and immune manifestations in myelodysplasia: a multicenter retrospective study

A De Hollanda, A Beucher, D Henrion… - Arthritis care & …, 2011 - Wiley Online Library
Objective The presence of systemic and/or immune manifestations in myelodysplasia has
been currently reported. The influence of these manifestations on the natural outcome of …

Autoimmune disorders are common in myelodysplastic syndrome patients and confer an adverse impact on outcomes

J Montoro, L Gallur, B Merchán, A Molero, E Roldán… - Annals of …, 2018 - Springer
The coexistence of autoimmune disorders (AD) in patients with myelodysplastic syndrome
(MDS) or chronic myelomonocytic leukemia (CMML) has been widely recognized, although …

Myelodysplasic syndromes: a comprehensive review

DVT Catenacci, GJ Schiller - Blood reviews, 2005 - Elsevier
Myelodysplastic syndromes (MDS) are a set of oligoclonal disorders of hematopoietic stem
cells characterized by ineffective hematopoiesis that manifest clinically as anemia …

Spectrum of autoimmune diseases and systemic inflammatory syndromes in patients with chronic myelomonocytic leukemia

MF Zahid, D Barraco, TL Lasho, C Finke… - Leukemia & …, 2017 - Taylor & Francis
Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic stem cell disorder with
overlap** features of myelodysplastic syndromes (MDS) and myeloproliferative …

Myelodysplastic syndromes and autoimmune diseases—case series and review of literature

O Al Ustwani, LA Ford, SJN Sait, AMW Block… - Leukemia research, 2013 - Elsevier
Our objective was to recognize the association of autoimmune diseases (AD) in patients with
myelodysplastic syndromes (MDS) and understand how this association could affect …