The non-canonical Wnt/Ca2+ signaling cascade is less characterized than their canonical
counterpart, the Wnt/b-catenin pathway. The non-canonical Wnt signaling pathways are …

The extracellular antagonists of the Wnt signalling pathway can be divided into two broad
classes. Both classes of molecule prevent ligand-receptor interactions, but by different …

The Wnt signaling pathway, named for its most upstream ligands, the Wnts, is involved in
various differentiation events during embryonic development and leads to tumor formation …

The Wnts comprise a large class of secreted proteins that control essential developmental
processes such as embryonic patterning, cell growth, migration, and differentiation. In the …

Wnt signaling is a complex pathway in which β-catenin is typically viewed as a central
mediator. However, within the past 15 years, at least three Wnt-mediated pathways have …

Wnt5a is a representative ligand that activates the β‐catenin‐independent pathways.
Because the β‐catenin‐independent pathway includes multiple signalling cascades in …

Wnt signaling controls a variety of developmental processes. The canonical Wnt/β-catenin
pathway functions to stabilize β-catenin, and the noncanonical Wnt/Ca2+ pathway activates …

Fertilization calcium waves are introduced, and the evidence from which we can infer
general mechanisms of these waves is presented. The two main classes of hypotheses put …

During development, vertebrate embryos undergo dramatic changes in shape. The
lengthening and narrowing of a field of cells, termed convergent extension, contributes to a …

At the heart of the canonical Wnt signaling cascade, adenomatous polyposis coli (APC),
axin, and GSK3 constitute the so-called destruction complex, which controls the stability of β …